Detailed view for TGME49_247390

Basic information

TDR Targets ID: 258739
Toxoplasma gondii, ATPase, AAA family protein
Source Database / ID:  ToxoDB 

pI: 5.2797 | Length (AA): 3910 | MW (Da): 421734 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0017111   nucleoside-triphosphatase activity  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1343 1936 1qvr (A) 44 609 18.00 0.000000000034 1 0.01 1.61
1450 1641 1ixz (A) 153 320 42.00 0 1 0.47 -1.14
20 92 2kr0 (A) 187 261 30.00 0.56 0.02 0.11697 1.15
514 707 4uos (A) 0 186 11.00 0 0.01 0.115216 -0.73
534 593 5chl (A) 5 67 38.00 0.26 0.01 0.329045 0.09
572 672 5cwq (A) 4 91 32.00 0.38 0.4 0.281531 -0.44
1437 1790 2v1u (A) 19 341 18.00 0 1 -0.143863 1.23
1449 1640 5e7p (A) 481 647 50.00 0 1 0.535805 -0.55
1449 1715 5eqt (A) 102 338 40.00 0 1 0.361986 0.08
1449 1651 2ce7 (A) 157 335 40.00 0 1 0.336518 -0.56
1450 1663 3cf0 (A) 474 663 42.00 0 1 0.462431 -0.26
1450 1680 1lv7 (A) 152 357 35.00 0 1 0.271679 0.06
1924 2281 4mt0 (A) 99 460 28.00 0.29 0.22 0.0782601 1.47
2403 2514 5j0l (D) 4 118 15.00 0.45 0.04 0.253944 -1.5
2403 2569 5cwj (A) 4 161 18.00 0.0086 0.25 0.284011 -1.25
2576 2843 4x0j (A) 39 296 12.00 0 0.06 0.185142 -1.11
2601 2827 5cwp (A) 10 225 16.00 0 0.03 0.209656 -1.21
2612 2716 5hmo (A) 796 890 32.00 0.049 0.03 0.300554 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. Gregory Fritz HM
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile ME49 merozoite, ME49 Bradyzoite. Hehl AB Sibley/Greg
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB

Orthologs

Ortholog group members (OG5_241314)

Species Accession Gene Product
Neospora caninum NCLIV_065330   ATPase, AAA family domain-containing protein, putative
Toxoplasma gondii TGME49_247390   ATPase, AAA family protein

Essentiality

TGME49_247390 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
TGME49_247390 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_247390 (Toxoplasma gondii), ATPase, AAA family protein
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