Detailed view for LmjF.35.1920

Basic information

TDR Targets ID: 25903
Leishmania major, 60S Ribosomal protein L36, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.8574 | Length (AA): 105 | MW (Da): 11892 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01158   Ribosomal protein L36e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005840   ribosome  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 105 4ilu (A) 66 166 29.00 0.059 0.33 1.06281 0.03
46 100 3p56 (B) 127 212 31.00 0.89 0.05 0.63451 1.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127134)

Species Accession Gene Product
Arabidopsis thaliana AT2G37600   60S ribosomal protein L36-1
Arabidopsis thaliana AT3G53740   60S ribosomal protein L36-2
Arabidopsis thaliana AT5G02450   60S ribosomal protein L36-3
Babesia bovis BBOV_II003460   60S ribosomal protein L36
Brugia malayi Bm1_16700   60S ribosomal protein L36
Caenorhabditis elegans CELE_F37C12.4   Protein RPL-36
Cryptosporidium hominis Chro.10191   ribosomal protein L36e
Cryptosporidium parvum cgd1_1660   60S ribosomal protein L36
Dictyostelium discoideum DDB_G0271668   S60 ribosomal protein L36
Drosophila melanogaster Dmel_CG7622   Ribosomal protein L36
Echinococcus granulosus EgrG_001035500   60S ribosomal protein L36
Entamoeba histolytica EHI_124330   60S ribosomal protein L36, putative
Entamoeba histolytica EHI_199940   60S ribosomal protein L36, putative
Entamoeba histolytica EHI_184480   60S ribosomal protein L36, putative
Echinococcus multilocularis EmuJ_001035500   60S ribosomal protein L36
Giardia lamblia GL50803_16114   Ribosomal protein L36-1
Homo sapiens ENSG00000130255   ribosomal protein L36
Leishmania braziliensis LbrM.21.0800   60S Ribosomal protein L36, putative
Leishmania braziliensis LbrM.34.1820   60S Ribosomal protein L36, putative
Leishmania donovani LdBPK_210800.1   60S ribosomal protein L36, putative
Leishmania donovani LdBPK_351900.1   60S ribosomal protein L36, putative
Leishmania infantum LinJ.35.1900   60S Ribosomal protein L36, putative
Leishmania infantum LinJ.21.0800   60S Ribosomal protein L36, putative
Leishmania major LmjF.35.1920   60S Ribosomal protein L36, putative
Leishmania major LmjF.21.0730   60S Ribosomal protein L36, putative
Leishmania mexicana LmxM.21.0730   60S Ribosomal protein L36, putative
Leishmania mexicana LmxM.34.1920   60S Ribosomal protein L36, putative
Loa Loa (eye worm) LOAG_04118   ribosomal protein L36
Mus musculus 102643292   protein MNN4-like
Mus musculus 100043718   predicted gene 4604
Mus musculus ENSMUSG00000057863   ribosomal protein L36
Neospora caninum NCLIV_015620   60S ribosomal protein L36, related
Oryza sativa 4327391   Os01g0840700
Oryza sativa 4339011   Os05g0459900
Plasmodium berghei PBANKA_0937700   60S ribosomal protein L36, putative
Plasmodium falciparum PF3D7_1109900   60S ribosomal protein L36
Plasmodium knowlesi PKNH_0907200   60S ribosomal protein L36, putative
Plasmodium vivax PVX_091145   60S ribosomal protein L36, putative
Plasmodium yoelii PY06787   Ribosomal protein L36e
Saccharomyces cerevisiae YMR194W   ribosomal 60S subunit protein L36A
Saccharomyces cerevisiae YPL249C-A   ribosomal 60S subunit protein L36B
Schistosoma japonicum Sjp_0201990   ko:K02920 large subunit ribosomal protein L36e, putative
Schistosoma mansoni Smp_063300   60S ribosomal protein L36e
Schmidtea mediterranea mk4.015684.00  
Schmidtea mediterranea mk4.004729.02  
Trypanosoma brucei gambiense Tbg972.10.1880   ribosomal protein L36, putative
Trypanosoma brucei gambiense Tbg972.9.9410   ribosomal protein L36, putative
Trypanosoma brucei Tb927.9.15210   ribosomal protein L36, putative
Trypanosoma brucei Tb927.10.1590   ribosomal protein L36, putative
Trypanosoma congolense TcIL3000_9_6360   ribosomal protein L36, putative
Trypanosoma cruzi TcCLB.506977.49   ribosomal protein L36, putative
Trypanosoma cruzi TcCLB.510767.20   60S ribosomal protein L36, putative
Trypanosoma cruzi TcCLB.509671.64   ribosomal protein L36, putative
Toxoplasma gondii TGME49_238250   ribosomal protein RPL36
Theileria parva TP04_0238   60S ribosomal protein L36, putative
Trichomonas vaginalis TVAG_433250   60S ribosomal protein L36e, putative
Trichomonas vaginalis TVAG_357930   60S ribosomal protein L36e, putative
Trichomonas vaginalis TVAG_042520   60S ribosomal protein L36e, putative
Trichomonas vaginalis TVAG_020530   60S ribosomal protein L36e, putative
Trichomonas vaginalis TVAG_207430   60S ribosomal protein L36e, putative
Trichomonas vaginalis TVAG_027320   60S ribosomal protein L36e, putative

Essentiality

LmjF.35.1920 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.244.2725 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.244.2725 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.244.2725 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.244.2725 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F37C12.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F37C12.4 Caenorhabditis elegans larval arrest wormbase
CELE_F37C12.4 Caenorhabditis elegans slow growth wormbase
CELE_F37C12.4 Caenorhabditis elegans sterile wormbase
PBANKA_0937700 Plasmodium berghei Essential plasmo
TGME49_238250 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.1920 (Leishmania major), 60S Ribosomal protein L36, putative
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