Detailed view for TGME49_319550

Basic information

TDR Targets ID: 259325
Toxoplasma gondii, membrane protein C17G8.08c, putative
Source Database / ID:  ToxoDB 

pI: 5.6131 | Length (AA): 343 | MW (Da): 36178 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01169   Uncharacterized protein family UPF0016

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 341 4k1c (A) 51 365 20.00 0 0.66 1.02433 0.43
144 228 2hsi (A) 98 202 37.00 0.5 0.21 0.469313 0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 merozoite, ME49 Oocyst. Hehl AB Fritz HM
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_128045)

Species Accession Gene Product
Arabidopsis thaliana AT1G25520   putative transmembrane protein
Arabidopsis thaliana AT5G36290   hypothetical protein
Arabidopsis thaliana AT1G68650   hypothetical protein
Brugia malayi Bm1_41280   uncharacterized hypothalamus protein HTMP
Candida albicans CaO19.11972   similar to S. cerevisiae YBR187W
Candida albicans CaO19.4496   similar to S. cerevisiae YBR187W
Caenorhabditis elegans CELE_Y54F10AL.1   Protein Y54F10AL.1, isoform B
Cryptosporidium hominis Chro.40056   CG4196-PC
Cryptosporidium parvum cgd4_420   signal peptide + 4 transmembrane domain protein
Drosophila melanogaster Dmel_CG42542   CG42542 gene product from transcript CG42542-RE
Echinococcus granulosus EgrG_000867100   transmembrane protein 165
Echinococcus multilocularis EmuJ_000867100   transmembrane protein 165
Homo sapiens ENSG00000134851   transmembrane protein 165
Leishmania braziliensis LbrM.19.0630   membrane protein, putative
Leishmania donovani LdBPK_190310.1   membrane protein, putative
Leishmania infantum LinJ.19.0310   membrane protein, putative
Leishmania major LmjF.19.0310   membrane protein, putative
Leishmania mexicana LmxM.19.0310   membrane protein, putative
Loa Loa (eye worm) LOAG_02681   hypothetical protein
Mus musculus ENSMUSG00000029234   transmembrane protein 165
Mycobacterium tuberculosis Rv3848   Probable conserved transmembrane protein
Mycobacterium ulcerans MUL_5020   hypothetical protein
Neospora caninum NCLIV_010610   hypothetical protein
Oryza sativa 4345649   Os08g0433100
Oryza sativa 4350494   Os11g0472500
Oryza sativa 4346111   Os08g0528500
Onchocerca volvulus OVOC8708   Transmembrane protein 165 homolog
Saccharomyces cerevisiae YBR187W   Gdt1p
Schistosoma japonicum Sjp_0204130   Transmembrane protein 165, putative
Schistosoma mansoni Smp_096780.1   transmembrane protein htp-1 related
Schistosoma mansoni Smp_096780.2   transmembrane protein htp-1 related
Schmidtea mediterranea mk4.016386.00   Transmembrane protein 165
Schmidtea mediterranea mk4.004497.00   Transmembrane protein 165
Trypanosoma cruzi TcCLB.506211.50   membrane protein, putative
Trypanosoma cruzi TcCLB.508895.70   membrane protein, putative
Toxoplasma gondii TGME49_319550   membrane protein C17G8.08c, putative

Essentiality

TGME49_319550 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
TGME49_319550 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_319550 (Toxoplasma gondii), membrane protein C17G8.08c, putative
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