Detailed view for TGME49_310440

Basic information

TDR Targets ID: 259392
Toxoplasma gondii, membrane occupation and recognition nexus protein MORN1
Source Database / ID:  ToxoDB 

pI: 5.8579 | Length (AA): 363 | MW (Da): 40890 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02493   MORN repeat

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
47 182 1h3i (A) 53 169 35.00 0.000015 0.11 0.321256 1.09
96 182 1n6c (A) 79 169 32.00 0.11 0.47 0.460269 0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 merozoite. Gregory Hehl AB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile ME49 Oocyst. Fritz HM
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_128972)

Species Accession Gene Product
Babesia bovis BBOV_IV001320   phosphatidylinositol-4-phosphate 5-kinase, putative
Cryptosporidium hominis Chro.60298   phosphatidylinositol-4-phosphate 5-kinase, 11335-7537
Cryptosporidium parvum cgd6_2570   MORN domain repeat containing protein
Dictyostelium discoideum DDB_G0276561   hypothetical protein
Giardia lamblia GL50803_7261   Phosphatidylinositol-4-phosphate 5-kinase, putative
Homo sapiens ENSG00000169402   radial spoke head 10 homolog B2 (Chlamydomonas)
Homo sapiens ENSG00000155026   radial spoke head 10 homolog B (Chlamydomonas)
Leishmania braziliensis LbrM.30.3350   hypothetical protein, conserved
Leishmania donovani LdBPK_303360.1   MORN repeat-containing protein 1
Leishmania infantum LinJ.30.3360   hypothetical protein, conserved
Leishmania major LmjF.30.3310   hypothetical protein, conserved
Leishmania mexicana LmxM.29.3310   hypothetical protein, conserved
Mus musculus ENSMUSG00000075569   radial spoke head 10 homolog B (Chlamydomonas)
Neospora caninum NCLIV_054520   hypothetical protein
Plasmodium berghei PBANKA_0515200   MORN repeat-containing protein 1, putative
Plasmodium falciparum PF3D7_1031200   MORN repeat-containing protein 1
Plasmodium knowlesi PKNH_0615900   MORN repeat-containing protein 1, putative
Plasmodium vivax PVX_111165   MORN repeat-containing protein 1, putative
Plasmodium yoelii PY05981   MORN repeat, putative
Schistosoma japonicum Sjp_0301120   IPR003409,MORN motif,domain-containing
Schistosoma japonicum Sjp_0012290   Phosphatidylinositol-4-phosphate 5-kinase 6, putative
Schistosoma mansoni Smp_129740   hypothetical protein
Schmidtea mediterranea mk4.001178.02  
Trypanosoma brucei gambiense Tbg972.6.4490   CMRP,flagellar component
Trypanosoma brucei Tb927.6.4670   MORN repeat-containing protein 1
Trypanosoma congolense TcIL3000_6_4110   MORN repeat-containing protein 1
Trypanosoma cruzi TcCLB.511729.60   MORN repeat-containing protein 1
Toxoplasma gondii TGME49_310440   membrane occupation and recognition nexus protein MORN1
Theileria parva TP01_0158   hypothetical protein, conserved
Trichomonas vaginalis TVAG_100020   morn protein, putative

Essentiality

TGME49_310440 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4670 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0515200 Plasmodium berghei Dispensable plasmo
TGME49_310440 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_310440 (Toxoplasma gondii), membrane occupation and recognition nexus protein MORN1
Title for this comment
Comment