pI: 4.9224 |
Length (AA): 466 |
MW (Da): 49582 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
358 | 453 | 2pe8 (A) | 302 | 397 | 54.00 | 0 | 1 | 0.876409 | -0.82 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_129437)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G30480 | DNA-damage-repair/toleration protein DRT111 |
Babesia bovis | BBOV_IV009160 | conserved hypothetical protein |
Brugia malayi | Bm1_36780 | G-patch domain containing protein |
Caenorhabditis elegans | CELE_F58B3.7 | Protein F58B3.7 |
Dictyostelium discoideum | DDB_G0270450 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG17540 | CG17540 gene product from transcript CG17540-RB |
Echinococcus granulosus | EgrG_000112500 | splicing factor 45 |
Echinococcus multilocularis | EmuJ_000112500 | splicing factor 45 |
Homo sapiens | ENSG00000134453 | RNA binding motif protein 17 |
Loa Loa (eye worm) | LOAG_03171 | G-patch domain-containing protein |
Mus musculus | ENSMUSG00000037197 | RNA binding motif protein 17 |
Neospora caninum | NCLIV_051870 | DNA repair enzyme, putative |
Onchocerca volvulus | OVOC4548 |
|
Plasmodium berghei | PBANKA_1317700 | RNA-binding protein, putative |
Plasmodium falciparum | PF3D7_1454000 | RNA-binding protein, putative |
Plasmodium knowlesi | PKNH_1228100 | RNA-binding protein, putative |
Plasmodium vivax | PVX_117780 | RNA-binding protein, putative |
Plasmodium yoelii | PY00795 | G-patch domain, putative |
Schistosoma japonicum | Sjp_0309900 | expressed protein |
Schistosoma japonicum | Sjp_0023820 | Splicing factor 45, putative |
Schistosoma mansoni | Smp_161750 | hypothetical protein |
Schmidtea mediterranea | mk4.001549.03 | Splicing factor 45 |
Trypanosoma congolense | TcIL3000_7_4190 | hypothetical protein |
Toxoplasma gondii | TGME49_214820 | G-patch domain-containing protein |
Theileria parva | TP01_0856 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_214820 this record | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3