Detailed view for TGME49_206550

Basic information

TDR Targets ID: 259674
Toxoplasma gondii, hypothetical protein
Source Database / ID:  ToxoDB 

pI: 6.8841 | Length (AA): 5044 | MW (Da): 547598 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14874   Flagellar-associated PapD-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0005198   structural molecule activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
119 233 2ys4 (A) 8 122 37.00 0 0.93 0.413199 0.3
367 477 2e6j (A) 2 112 32.00 0.00096 1 0.464606 -0.69
1643 1726 4beh (B) 223 302 28.00 0.56 0.11 0.124753 1.06
2165 2282 2mqa (A) 18 136 13.00 0 0.01 0.135294 -0.32
3272 3335 1dfb (H) 106 158 47.00 0.52 0.12 0.00278834 2.65
4160 4276 3r4t (A) 60 186 29.00 0.1 0.15 -0.00370412 1.35
4379 4493 3qbt (B) 563 678 17.00 0.081 0.18 0.0903994 0.14
4959 5044 2d7o (A) 14 101 22.00 0.31 0.1 0.12365 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB

Orthologs

Ortholog group members (OG5_128968)

Species Accession Gene Product
Echinococcus granulosus EgrG_000863000   leucine rich repeat flightless interacting
Echinococcus granulosus EgrG_001163700   hydrocephalus inducing
Echinococcus multilocularis EmuJ_000863000   leucine rich repeat flightless interacting
Echinococcus multilocularis EmuJ_001163700   hydrocephalus inducing
Homo sapiens ENSG00000157423   HYDIN, axonemal central pair apparatus protein
Homo sapiens 101930373   hydrocephalus-inducing protein homolog
Leishmania braziliensis LbrM.17.0870   hypothetical protein, conserved
Leishmania donovani LdBPK_301810.1   Zeta toxin, putative
Leishmania infantum LinJ.30.1810   hypothetical protein, conserved
Leishmania major LmjF.30.1810   hypothetical protein, conserved
Leishmania mexicana LmxM.29.1810   hypothetical protein, conserved
Mus musculus ENSMUSG00000059854   HYDIN, axonemal central pair apparatus protein
Neospora caninum NCLIV_044250   hypothetical protein, conserved
Schistosoma japonicum Sjp_0003880   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0104760   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0304440   Leucine-rich repeat flightless-interacting protein 2, putative
Schistosoma japonicum Sjp_0003890   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0003900   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0118680   hypothetical protein
Schistosoma japonicum Sjp_0109230   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0118340   Hydrocephalus-inducing protein, putative
Schistosoma japonicum Sjp_0003910   Hydrocephalus-inducing protein, putative
Schistosoma mansoni Smp_175450   hypothetical protein
Schistosoma mansoni Smp_175460   hypothetical protein
Schmidtea mediterranea mk4.000152.18   Hydrocephalus-inducing protein homolog
Trypanosoma brucei gambiense Tbg972.6.2940   Hydin,flagellar component
Trypanosoma brucei Tb927.6.3150   Hydin
Trypanosoma congolense TcIL3000_0_11680   Hydin
Trypanosoma cruzi TcCLB.509173.9   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509171.100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507023.220   hypothetical protein, conserved
Toxoplasma gondii TGME49_206550   hypothetical protein
Trichomonas vaginalis TVAG_481960   conserved hypothetical protein
Trichomonas vaginalis TVAG_129800   conserved hypothetical protein
Trichomonas vaginalis TVAG_241570   conserved hypothetical protein
Trichomonas vaginalis TVAG_169860   conserved hypothetical protein
Trichomonas vaginalis TVAG_130090   conserved hypothetical protein
Trichomonas vaginalis TVAG_309160   conserved hypothetical protein
Trichomonas vaginalis TVAG_449190   conserved hypothetical protein
Trichomonas vaginalis TVAG_412510   conserved hypothetical protein
Trichomonas vaginalis TVAG_041110   conserved hypothetical protein
Trichomonas vaginalis TVAG_069480   conserved hypothetical protein
Trichomonas vaginalis TVAG_457560   conserved hypothetical protein

Essentiality

TGME49_206550 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.3150 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_206550 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_206550 (Toxoplasma gondii), hypothetical protein
Title for this comment
Comment