Detailed view for TGME49_312220

Basic information

TDR Targets ID: 259774
Toxoplasma gondii, mitochondrial inner membrane translocase subunit TIM17, putative
Source Database / ID:  ToxoDB 

pI: 9.1063 | Length (AA): 213 | MW (Da): 22613 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02466   Tim17/Tim22/Tim23/Pmp24 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005743   mitochondrial inner membrane  
GO:0008565   protein transporter activity  
GO:0015031   protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 merozoite, ME49 Oocyst. Hehl AB Fritz HM
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_128266)

Species Accession Gene Product
Arabidopsis thaliana AT2G37410   mitochondrial import inner membrane translocase subunit Tim17-2
Arabidopsis thaliana AT1G20350   translocase inner membrane subunit 17-1
Babesia bovis BBOV_IV008220   mitochondrial import inner membrane translocase subunit Tim17, putative
Brugia malayi Bm1_45800   Probable mitochondrial import inner membrane translocase subunitTim17
Candida albicans CaO19.150   similar to S. cerevisiae TIM17 (YJL143W) mitochondrial import inner membrane translocase
Candida albicans CaO19.7790   similar to S. cerevisiae TIM17 (YJL143W) mitochondrial import inner membrane translocase
Caenorhabditis elegans CELE_E04A4.5   Protein E04A4.5
Cryptosporidium hominis Chro.20443   mitochondrial import inner membrane translocase subunit tim17
Cryptosporidium parvum cgd2_4140   mitochondrial import inner membrane translocase subunit tim17
Dictyostelium discoideum DDB_G0287627   mitochondrial import inner membrane translocase subunit 17
Drosophila melanogaster Dmel_CG40451   CG40451 gene product from transcript CG40451-RA
Drosophila melanogaster Dmel_CG1158   CG1158 gene product from transcript CG1158-RA
Echinococcus granulosus EgrG_000784200   mitochondrial import inner membrane translocase
Echinococcus granulosus EgrG_000838900   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_000784200   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_000838900   mitochondrial import inner membrane translocase
Homo sapiens ENSG00000134375   translocase of inner mitochondrial membrane 17 homolog A (yeast)
Loa Loa (eye worm) LOAG_08617   hypothetical protein
Mus musculus 21855   translocase of inner mitochondrial membrane 17b
Mus musculus 21854   translocase of inner mitochondrial membrane 17a
Neospora caninum NCLIV_055810   hypothetical protein
Oryza sativa 4333113   Os03g0415500
Oryza sativa 4343846   Os07g0604500
Onchocerca volvulus OVOC8661   Putative mitochondrial import inner membrane translocase subunit tim17
Plasmodium berghei PBANKA_1010100   mitochondrial import inner membrane translocase subunit TIM17, putative
Plasmodium falciparum PF3D7_1434700   mitochondrial import inner membrane translocase subunit TIM17, putative
Plasmodium knowlesi PKNH_0421300   mitochondrial import inner membrane translocase subunit TIM17, putative
Plasmodium vivax PVX_084800   mitochondrial import inner membrane translocase subunit TIM17, putative
Plasmodium yoelii PY02558   mitochondrial import inner membrane translocase subunit tim17
Saccharomyces cerevisiae YJL143W   protein transporter TIM17
Schistosoma japonicum Sjp_0202130   Mitochondrial import inner membrane translocase subunit Tim17-A, putative
Schistosoma mansoni Smp_155870   mitochondrial import inner membrane translocase subunit Tim17
Schmidtea mediterranea mk4.006978.01   Putative mitochondrial import inner membrane translocase subunit tim17
Schmidtea mediterranea mk4.003693.01   Putative mitochondrial import inner membrane translocase subunit tim17
Toxoplasma gondii TGME49_312220   mitochondrial inner membrane translocase subunit TIM17, putative
Theileria parva TP01_0951   mitochondrial import inner membrane translocase subunit tim17, putative

Essentiality

TGME49_312220 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_E04A4.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_E04A4.5 Caenorhabditis elegans larval arrest wormbase
CELE_E04A4.5 Caenorhabditis elegans slow growth wormbase
YJL143W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1010100 Plasmodium berghei Slow plasmo
TGME49_312220 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_312220 (Toxoplasma gondii), mitochondrial inner membrane translocase subunit TIM17, putative
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