Detailed view for TGME49_207080

Basic information

TDR Targets ID: 259945
Toxoplasma gondii, histone lysine acetyltransferase MYST-B
Source Database / ID:  ToxoDB 

pI: 8.6727 | Length (AA): 1086 | MW (Da): 120876 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01853   MOZ/SAS family
PF11717   RNA binding activity-knot of a chromodomain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016573   histone acetylation  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0004402   histone acetyltransferase activity  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
790 1035 1fy7 (A) 162 395 47.00 0 1 0.83 -0.99
793 1035 2giv (A) 4 234 50.00 0 1 0.69 -1.23
818 848 1m36 (A) 2 32 32.00 0.0000014 0.05 0.4 -0.64
1 441 4k6j (A) 679 1182 10.00 0 0.02 0.433377 -0.31
39 189 2k3n (A) 15 160 28.00 0.0097 0.04 0.345442 0
285 356 5hmo (A) 816 892 36.00 0.047 0.14 0.614698 -2.82
285 474 4uos (A) 11 185 17.00 0 0.15 0.463254 -2.43
633 688 2rnz (A) 30 85 38.00 0.16 0.46 0.232965 0.77
782 1076 5j9u (E) 154 444 42.00 0 1 0.808639 -0.51
795 1071 4dnc (A) 179 448 47.00 0 1 0.830364 -1.04
796 1065 2ou2 (A) 181 452 50.00 0 1 0.764619 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile ME49 Bradyzoite. Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite. Gregory Hehl AB
Show/Hide expression data references
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_126735)

Species Accession Gene Product
Arabidopsis thaliana AT5G64610   MYST family histone acetyltransferase 1
Arabidopsis thaliana AT5G09740   MYST-like histone acetyltransferase 2
Babesia bovis BBOV_IV010860   histone acetyltransferase protein, putative
Brugia malayi Bm1_36310   histone acetyltransferase MYST1
Brugia malayi Bm1_24465   histone acetyltransferase
Brugia malayi Bm1_07755   hypothetical protein
Candida albicans CaO19.12871   similar to S. cerevisiae ESA1 (YOR244W) NuA4 histone acetyltransferase complex catalytic subunit
Candida albicans CaO19.5416   similar to S. cerevisiae ESA1 (YOR244W) NuA4 histone acetyltransferase complex catalytic subunit
Candida albicans CaO19.10074   potential histone acetyltransferase similar to S. cerevisiae SAS3 (YBL052C) catalytic subunit of the HAT complex NuA3
Candida albicans CaO19.2540   potential histone acetyltransferase similar to S. cerevisiae SAS3 (YBL052C) catalytic subunit of the HAT complex NuA3
Caenorhabditis elegans CELE_K03D10.3   Protein MYS-2
Caenorhabditis elegans CELE_VC5.4   Protein MYS-1
Cryptosporidium hominis Chro.60300   histone acetyltransferase
Cryptosporidium hominis Chro.80035   MOZ/SAS family
Cryptosporidium parvum cgd8_250   MOZ/SAS histone aceytl-transferase
Cryptosporidium parvum cgd6_2590   histone acetyltransferase (MYST family); chromo domain + C2H2 domain
Dictyostelium discoideum DDB_G0275017   HAM group protein
Dictyostelium discoideum DDB_G0279699   HAM group protein
Drosophila melanogaster Dmel_CG3025   males absent on the first
Drosophila melanogaster Dmel_CG5229   chameau
Drosophila melanogaster Dmel_CG6121   CG6121 gene product from transcript CG6121-RA
Echinococcus granulosus EgrG_000898000   myst histone acetyltransferase 1
Echinococcus granulosus EgrG_001181900   histone acetyltransferase tip60
Entamoeba histolytica EHI_142000   histone acetyltransferase, putative
Echinococcus multilocularis EmuJ_001181900   histone acetyltransferase tip60
Echinococcus multilocularis EmuJ_000898000   myst histone acetyltransferase 1
Giardia lamblia GL50803_2851   Histone acetyltransferase MYST2
Giardia lamblia GL50803_17263   Histone methyltransferase MYST1
Homo sapiens ENSG00000103510   K(lysine) acetyltransferase 8
Homo sapiens ENSG00000172977   K(lysine) acetyltransferase 5
Homo sapiens ENSG00000136504   K(lysine) acetyltransferase 7
Leishmania braziliensis LbrM.14.0140   histone acetyltransferase, putative
Leishmania donovani LdBPK_140140.1   histone acetyltransferase, putative
Leishmania infantum LinJ.14.0140   histone acetyltransferase, putative
Leishmania major LmjF.14.0140   histone acetyltransferase, putative
Leishmania mexicana LmxM.14.0140   histone acetyltransferase, putative
Loa Loa (eye worm) LOAG_04899   histone acetyltransferase MYST1
Loa Loa (eye worm) LOAG_08870   histone acetyltransferase
Loa Loa (eye worm) LOAG_08908   histone acetyltransferase MYST1
Mus musculus ENSMUSG00000038909   K(lysine) acetyltransferase 7
Mus musculus ENSMUSG00000030801   K(lysine) acetyltransferase 8
Mus musculus ENSMUSG00000024926   K(lysine) acetyltransferase 5
Neospora caninum NCLIV_053000   hypothetical protein
Neospora caninum NCLIV_011190   MOZ/SAS family protein, related
Oryza sativa 4343971   Os07g0626600
Onchocerca volvulus OVOC4147  
Onchocerca volvulus OVOC2189   Histone acetyltransferase KAT8 homolog
Plasmodium berghei PBANKA_0929500   histone acetyltransferase, putative
Plasmodium falciparum PF3D7_1118600   histone acetyltransferase
Plasmodium knowlesi PKNH_0916300   histone acetyltransferase, putative
Plasmodium vivax PVX_091565   histone acetyltransferase, putative
Plasmodium yoelii PY00909   MOZ/SAS family, putative
Saccharomyces cerevisiae YOR244W   NuA4 histone acetyltransferase complex catalytic subunit ESA1
Saccharomyces cerevisiae YBL052C   Sas3p
Schistosoma japonicum Sjp_0006470   ko:K00653 histone acetyltransferase [EC2.3.1.48], putative
Schistosoma japonicum Sjp_0213620   ko:K00653 histone acetyltransferase [EC2.3.1.48], putative
Schistosoma japonicum Sjp_0123150   Histone acetyltransferase Tip60, putative
Schistosoma mansoni Smp_053140   tip60
Schistosoma mansoni Smp_194520   myst histone acetyltransferase
Schmidtea mediterranea mk4.000527.10   Histone acetyltransferase KAT8
Schmidtea mediterranea mk4.002270.00   Histone acetyltransferase KAT5
Schmidtea mediterranea mk4.007806.00   Putative myst histone acetyltransferase
Trypanosoma brucei gambiense Tbg972.7.5160   histone acetyltransferase, putative
Trypanosoma brucei Tb927.7.4560   Histone acetyltransferase 1
Trypanosoma congolense TcIL3000_7_3790   histone acetyltransferase, putative
Trypanosoma cruzi TcCLB.506605.160   histone acetyltransferase, putative
Trypanosoma cruzi TcCLB.511239.150   histone acetyltransferase, putative
Toxoplasma gondii TGME49_207080   histone lysine acetyltransferase MYST-B
Toxoplasma gondii TGME49_318330   histone lysine acetyltransferase MYST-A
Theileria parva TP01_0749   histone acetyltransferase, putative
Trichomonas vaginalis TVAG_395430   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_296330   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_359840   tip60, putative
Trichomonas vaginalis TVAG_216320   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_296750   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_233420   mst1, putative
Trichomonas vaginalis TVAG_345100   tip60, putative
Trichomonas vaginalis TVAG_131130   myst histone acetyltransferase, putative

Essentiality

TGME49_207080 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.4560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.4560 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.4560 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.4560 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_VC5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_VC5.4 Caenorhabditis elegans larval lethal wormbase
CELE_VC5.4 Caenorhabditis elegans slow growth wormbase
CELE_VC5.4 Caenorhabditis elegans sterile wormbase
YOR244W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0929500 Plasmodium berghei Essential plasmo
TGME49_207080 this record Toxoplasma gondii Essentiality uncertain sidik
TGME49_318330 Toxoplasma gondii Essentiality uncertain sidik
TGME49_207080 this record Toxoplasma gondii Probably essential sidik
TGME49_318330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens K(lysine) acetyltransferase 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TGME49_207080 (Toxoplasma gondii), histone lysine acetyltransferase MYST-B
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