Detailed view for TGME49_203030

Basic information

TDR Targets ID: 260068
Toxoplasma gondii, N-methyl-D-aspartate receptor-associated protein
Source Database / ID:  ToxoDB 

pI: 7.0112 | Length (AA): 342 | MW (Da): 37345 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01027   Inhibitor of apoptosis-promoting Bax1

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 113 2dkv (A) 149 261 28.00 0.58 0.11 0.517113 -0.22
7 66 4dmu (A) 5 225 29.00 0 0.01 0.273939 0.91
8 99 2fx5 (A) 148 249 39.00 0.043 0.28 0.523406 0.09
129 340 4pgr (A) 9 208 25.00 0 0.52 0.795383 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_126826)

Species Accession Gene Product
Arabidopsis thaliana AT1G03070   protein lifeguard 4
Arabidopsis thaliana AT4G14730   Bax inhibitor-1 family protein
Arabidopsis thaliana AT4G15470   Bax inhibitor-1 like protein
Arabidopsis thaliana AT3G63310   BRZ-INSENSITIVE-LONG HYPOCOTYLS 4
Arabidopsis thaliana AT4G02690   BAX inhibitor-1 motif-containing protein
Babesia bovis BBOV_I003050   conserved hypothetical protein
Brugia malayi Bm1_32105   Uncharacterized protein family UPF0005 containing protein
Brugia malayi Bm1_06170   Uncharacterized protein family UPF0005 containing protein
Candida albicans CaO19.916   similar to Aspergillus nidulans orf
Caenorhabditis elegans CELE_B0563.4   Protein TMBI-4
Caenorhabditis elegans CELE_F40F9.2   Protein TAG-120
Cryptosporidium hominis Chro.40302   N-methyl-D-aspartate receptor-associated protein CG3798-PC
Cryptosporidium parvum cgd4_2680   N-methyl-D-aspartate receptor-associated protein, 7 transmembrane domain protein
Chlamydia trachomatis CT_819   hypothetical protein
Drosophila melanogaster Dmel_CG3814   CG3814 gene product from transcript CG3814-RB
Drosophila melanogaster Dmel_CG9722   CG9722 gene product from transcript CG9722-RA
Drosophila melanogaster Dmel_CG3798   N-methyl-D-aspartate receptor-associated protein
Escherichia coli b0786   UPF0005 family inner membrane protein
Echinococcus granulosus EgrG_001047100   NMDA receptor glutamate binding chain
Echinococcus granulosus EgrG_000536000   transmembrane BAX inhibitor motif containing
Echinococcus multilocularis EmuJ_000536000   transmembrane BAX inhibitor motif containing
Echinococcus multilocularis EmuJ_001047100   NMDA receptor glutamate binding chain
Homo sapiens ENSG00000178719   glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Homo sapiens 51643   transmembrane BAX inhibitor motif containing 4
Loa Loa (eye worm) LOAG_02358   hypothetical protein
Loa Loa (eye worm) LOAG_08912   hypothetical protein
Mus musculus ENSMUSG00000022564   glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Mus musculus ENSMUSG00000020225   transmembrane BAX inhibitor motif containing 4
Mus musculus ENSMUSG00000014529   transmembrane BAX inhibitor motif containing 7
Neospora caninum NCLIV_021890   hypothetical protein
Neospora caninum NCLIV_065900   hypothetical protein, conserved
Neospora caninum NCLIV_053810   Os03g0795800 protein, related
Oryza sativa 4350786   Os11g0581900
Oryza sativa 4342545   Os07g0177200
Oryza sativa 4342546   Os07g0177300
Oryza sativa 4334416   Os03g0795600
Oryza sativa 4338736   Os05g0402300
Oryza sativa 4334085   Os03g0745600
Oryza sativa 4334417   Os03g0795800
Plasmodium berghei PBANKA_1461400   bax inhibitor 1, putative
Plasmodium falciparum PF3D7_1248500   bax inhibitor 1, putative
Plasmodium knowlesi PKNH_1468200   bax inhibitor 1, putative
Plasmodium vivax PVX_101315   bax inhibitor 1, putative
Plasmodium yoelii PY00378   Drosophila melanogaster CG3814 gene product
Saccharomyces cerevisiae YNL305C   Bxi1p
Schistosoma japonicum Sjp_0038420   ko:K06890 grina; NMDA receptor glutamate-binding chain, putative
Schistosoma japonicum Sjp_0056520   Regulator of G-protein signaling 11, putative
Schistosoma japonicum Sjp_0056530   IPR000342,Regulator of G protein signalling,domain-containing
Schistosoma japonicum Sjp_0210150   ko:K06890 MBIM4; transmembrane BAX inhibitor motif containing 4, putative
Schistosoma japonicum Sjp_0204690   ko:K06890 NMDA receptor glutamate-binding chain, putative
Schistosoma mansoni Smp_181470   recs1 protein (responsive to centrifugal force and shear stressprotein 1 protein)
Schistosoma mansoni Smp_141370   z-protein (S1r protein)
Schistosoma mansoni Smp_150500   recs1 protein (responsive to centrifugal force and shear stressprotein 1 protein)
Schmidtea mediterranea mk4.009755.01  
Schmidtea mediterranea mk4.015116.00   Putative z-protein
Schmidtea mediterranea mk4.000952.02   Regulator of G-protein signaling egl-10
Schmidtea mediterranea mk4.000235.12  
Schmidtea mediterranea mk4.000235.13  
Schmidtea mediterranea mk4.000235.14  
Schmidtea mediterranea mk4.000770.03  
Toxoplasma gondii TGME49_249770   Nmda1 protein
Toxoplasma gondii TGME49_309560   nmda receptor glutamate-binding chain
Toxoplasma gondii TGME49_203030   N-methyl-D-aspartate receptor-associated protein
Theileria parva TP01_0535   N-methyl-aspartate receptor, putative
Theileria parva TP01_0534   N-methyl-aspartate receptor, putative
Wolbachia endosymbiont of Brugia malayi Wbm0490   integral membrane protein, interacts with FtsH

Essentiality

TGME49_203030 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
b0786 Escherichia coli non-essential goodall
TGME49_203030 this record Toxoplasma gondii Essentiality uncertain sidik
TGME49_309560 Toxoplasma gondii Essentiality uncertain sidik
TGME49_249770 Toxoplasma gondii Essentiality uncertain sidik
TGME49_203030 this record Toxoplasma gondii Probably non-essential sidik
TGME49_309560 Toxoplasma gondii Probably non-essential sidik
TGME49_249770 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_203030 (Toxoplasma gondii), N-methyl-D-aspartate receptor-associated protein
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