pI: 5.8758 |
Length (AA): 599 |
MW (Da): 64568 |
Paralog Number:
1181
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
166 | 594 | 4xbr (A) | 176 | 578 | 24.00 | 0 | 1 | 0.520194 | 1.02 |
174 | 588 | 5csh (A) | 4 | 324 | 23.00 | 0 | 1 | 0.585821 | 0.73 |
201 | 596 | 2b9h (A) | 2 | 317 | 22.00 | 0 | 0.89 | 0.478102 | 0.98 |
343 | 596 | 2cn8 (A) | 319 | 490 | 41.00 | 0.000000035 | 1 | 0.21684 | 1.04 |
343 | 453 | 3p1a (A) | 205 | 294 | 48.00 | 0.00015 | 1 | 0.448109 | -0.16 |
344 | 469 | 3q5i (A) | 163 | 270 | 40.00 | 0.00000014 | 0.96 | 0.538151 | -0.25 |
354 | 470 | 1bi8 (A) | 128 | 225 | 33.00 | 0.046 | 0.58 | 0.305126 | 0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Bradyzoite. | Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite. | Hehl AB |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Xenopus laevis | Aurora kinase B-B | 368 aa | 22.0% | 305 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 20.6% | 287 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 22.3% | 256 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 24.2% | 401 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 22.0% | 277 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 21.8% | 275 aa | Compounds | References |