pI: 4.6758 |
Length (AA): 394 |
MW (Da): 43853 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
190 | 413 | 1ej0 (A) | 32 | 209 | 34.00 | 0 | 1 | 0.61 | 0.27 |
62 | 113 | 5hzp (C) | 73 | 124 | 10.00 | 0 | 0 | 0.47168 | -2.6 |
62 | 113 | 5hhe (D) | 184 | 235 | 19.00 | 0 | 0 | 0.54668 | -2.45 |
94 | 314 | 2nyu (A) | 1 | 189 | 29.00 | 0.000000000006 | 1 | 0.691114 | 0.28 |
97 | 314 | 1ej0 (A) | 33 | 209 | 34.00 | 0 | 1 | 0.7675 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Ortholog group members (OG5_127766)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV009410 | rRNA methyltransferase, putative |
Brugia malayi | Bm1_44340 | protein R74.7 |
Candida albicans | CaO19.14043 | likely methyltransferase similar to S. cerevisiae TRM7 (YBR061C) cytoplasmic tRNA methyltransferase |
Candida albicans | CaO19.6751 | likely methyltransferase similar to S. cerevisiae TRM7 (YBR061C) cytoplasmic tRNA methyltransferase |
Caenorhabditis elegans | CELE_R74.7 | Protein R74.7 |
Cryptosporidium hominis | Chro.30118 | cell division protein |
Cryptosporidium parvum | cgd3_890 | ybr061c-like, FtsJ methylase |
Dictyostelium discoideum | DDB_G0280483 | rRNA -methyltransferase |
Drosophila melanogaster | Dmel_CG7009 | CG7009 gene product from transcript CG7009-RA |
Drosophila melanogaster | Dmel_CG5220 | CG5220 gene product from transcript CG5220-RA |
Echinococcus granulosus | EgrG_000476800 | cell division protein |
Echinococcus granulosus | EgrG_000476700 | phosphatidylinositol glycan biosynthesis class s |
Entamoeba histolytica | EHI_098730 | ribosomal RNA methyltransferase, putative |
Echinococcus multilocularis | EmuJ_000476700 | phosphatidylinositol glycan biosynthesis class s |
Echinococcus multilocularis | EmuJ_000476800 | cell division protein |
Giardia lamblia | GL50803_6055 | FtsJ-like protein |
Homo sapiens | ENSG00000068438 | FtsJ RNA methyltransferase homolog 1 (E. coli) |
Leishmania braziliensis | LbrM.02.0410 | FtsJ-like methyltransferase, putative |
Leishmania donovani | LdBPK_020350.1 | FtsJ-like methyltransferase, putative |
Leishmania infantum | LinJ.02.0350 | FtsJ-like methyltransferase, putative |
Leishmania major | LmjF.02.0380 | FtsJ-like methyltransferase, putative |
Leishmania mexicana | LmxM.02.0380 | FtsJ-like methyltransferase, putative |
Loa Loa (eye worm) | LOAG_05470 | hypothetical protein |
Mus musculus | ensembl-mmu:ENSMUSG00000031171 | FtsJ homolog 1 (E. coli) |
Neospora caninum | NCLIV_024280 | KLLA0F18414p, related |
Oryza sativa | 4342000 | Os06g0704900 |
Plasmodium berghei | PBANKA_0809800 | ribosomal RNA methyltransferase, putative |
Plasmodium falciparum | PF3D7_0908600 | ribosomal RNA methyltransferase, putative |
Plasmodium knowlesi | PKNH_0706600 | ribosomal RNA methyltransferase, putative |
Plasmodium vivax | PVX_098870 | ribosomal RNA methyltransferase, putative |
Plasmodium yoelii | PY05388 | putative cell division protein |
Saccharomyces cerevisiae | YBR061C | Trm7p |
Schistosoma japonicum | Sjp_0308520 | Putative ribosomal RNA methyltransferase CG5220, putative |
Schistosoma japonicum | Sjp_0096420 | IPR000777,Envelope glycoprotein GP120,domain-containing |
Schistosoma japonicum | Sjp_0218110 | ko:K02427 cell division protein methyltransferase FtsJ, putative |
Schistosoma mansoni | Smp_137590 | ribosomal RNA methyltransferase |
Schmidtea mediterranea | mk4.000825.05 | Putative tRNA |
Trypanosoma brucei gambiense | Tbg.972.2.1010 | ribosomal RNA methyltransferase, putative |
Trypanosoma brucei | Tb927.2.2450 | ribosomal RNA methyltransferase, putative |
Trypanosoma congolense | TcIL3000_0_50270 | ribosomal RNA methyltransferase, putative |
Trypanosoma cruzi | TcCLB.508741.290 | ribosomal RNA methyltransferase, putative |
Toxoplasma gondii | TGME49_263670 | ribosomal RNA large subunit methyltransferase FTSJ1, putative |
Theileria parva | TP01_0830 | hypothetical protein |
Trichomonas vaginalis | TVAG_092500 | ribosomal RNA methyltransferase, putative |
Trichomonas vaginalis | TVAG_319930 | ribosomal RNA methyltransferase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0577 | 23S rRNA methylase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.2450 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.2450 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.2450 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.2450 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_263670 this record | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3
2 literature references were collected for this gene.