pI: 9.0378 |
Length (AA): 338 |
MW (Da): 36994 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 218 | 5a4p (A) | 100 | 307 | 19.00 | 0.16 | 1 | 0.845523 | -0.59 |
27 | 137 | 2h2y (A) | 24 | 133 | 19.00 | 0 | 0.81 | 0.647002 | -1.36 |
27 | 162 | 2f4w (A) | 16 | 149 | 39.00 | 0 | 1 | 0.889967 | -1.18 |
27 | 116 | 2h2y (A) | 24 | 117 | 26.00 | 0.8 | 0.78 | 0.559772 | -0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128898)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G17000 | ubiquitin-conjugating enzyme E2 32 |
Caenorhabditis elegans | CELE_D1022.1 | Protein UBC-6, isoform B |
Cryptosporidium hominis | Chro.80443 | hypothetical protein |
Cryptosporidium parvum | cgd8_3850 | Ubc6p like ubiquiting conjugating enzyme E2, possible transmembrane domain at C |
Dictyostelium discoideum | DDB_G0281369 | hypothetical protein |
Echinococcus granulosus | EgrG_000406600 | Ubiquitin conjugating enzyme E2 J1 |
Entamoeba histolytica | EHI_049740 | ubiquitin-conjugating enzyme family protein |
Echinococcus multilocularis | EmuJ_000406600 | Ubiquitin conjugating enzyme E2 J1 |
Giardia lamblia | GL50803_5921 | Ubiquitin-conjugating enzyme E2-28.4 kDa |
Homo sapiens | ENSG00000198833 | ubiquitin-conjugating enzyme E2, J1 |
Leishmania braziliensis | LbrM.05.0910 | ubiquitin-conjugating enzyme, putative |
Leishmania donovani | LdBPK_050930.1 | ubiquitin-conjugating enzyme E2, putative |
Leishmania infantum | LinJ.05.0930 | ubiquitin-conjugating enzyme, putative |
Leishmania major | LmjF.05.0930 | ubiquitin-conjugating enzyme, putative |
Leishmania mexicana | LmxM.05.0930 | ubiquitin-conjugating enzyme, putative |
Loa Loa (eye worm) | LOAG_05499 | hypothetical protein |
Mus musculus | ENSMUSG00000028277 | ubiquitin-conjugating enzyme E2J 1 |
Neospora caninum | NCLIV_067330 | ubiquitin-conjugating enzyme e2, putative |
Oryza sativa | 4332614 | Os03g0308000 |
Schistosoma japonicum | Sjp_0212120 | ko:K10578 ubiquitin-conjugating enzyme E2 J1, putative |
Schistosoma japonicum | Sjp_0310290 | expressed protein |
Schistosoma mansoni | Smp_174670 | non-canonical ubiquitin conjugating enzyme |
Schmidtea mediterranea | mk4.001680.02 | Ubiquitin-conjugating enzyme E2 J1 |
Trypanosoma brucei gambiense | Tbg972.7.8160 | ubiquitin-conjugating enzyme, putative,non-canonical ubiquiting-conjugating enzyme 1, putative |
Trypanosoma brucei | Tb927.7.6960 | ubiquitin-conjugating enzyme E2, putative |
Trypanosoma congolense | TcIL3000_0_44030 | ubiquitin-conjugating enzyme E2, putative |
Trypanosoma cruzi | TcCLB.508387.100 | ubiquitin-conjugating enzyme E2, putative |
Trypanosoma cruzi | TcCLB.506789.200 | ubiquitin-conjugating enzyme E2, putative |
Toxoplasma gondii | TGME49_278670 | ubiquitin-conjugating enzyme subfamily protein |
Trichomonas vaginalis | TVAG_066800 | ubiquitin-conjugating enzyme E2 j2, putative |
Trichomonas vaginalis | TVAG_091080 | non-canonical ubiquitin conjugating enzyme, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.6960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.6960 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.6960 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.6960 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_D1022.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_D1022.1 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_278670 this record | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.