pI: 8.6083 |
Length (AA): 218 |
MW (Da): 23682 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
60 | 218 | 4m1n (A) | 2 | 159 | 78.00 | 0 | 1 | 1.80586 | -2.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 merozoite, ME49 Oocyst. | Hehl AB Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Ortholog group members (OG5_127729)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G57870 | SUMO-conjugating enzyme SCE1 |
Babesia bovis | BBOV_I005060 | ubiquitin conjugating enzyme, putative |
Babesia bovis | BBOV_I005050 | ubiquitin conjugating enzyme, putative |
Brugia malayi | Bm1_40505 | ube2i2 protein |
Candida albicans | CaO19.13782 | ubiquitin-conjugating enzyme |
Candida albicans | CaO19.6424 | ubiquitin-conjugating enzyme |
Caenorhabditis elegans | CELE_F29B9.6 | Protein UBC-9 |
Cryptosporidium parvum | cgd7_2840 | ubiquitin conjugating enzyme, putative |
Dictyostelium discoideum | DDB_G0287693 | hypothetical protein |
Dictyostelium discoideum | DDB_G0287153 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3018 | lesswright |
Echinococcus granulosus | EgrG_000452700 | ubiquitin conjugating enzyme e2 i |
Entamoeba histolytica | EHI_147470 | ubiquitin-conjugating enzyme family protein |
Entamoeba histolytica | EHI_178500 | ubiquitin-conjugating enzyme family protein |
Echinococcus multilocularis | EmuJ_000452700 | ubiquitin conjugating enzyme e2 i |
Giardia lamblia | GL50803_24068 | UBC3 |
Homo sapiens | ENSG00000103275 | ubiquitin-conjugating enzyme E2I |
Leishmania braziliensis | LbrM.02.0420 | ubiquitin-conjugating enzyme e2, putative |
Leishmania donovani | LdBPK_020360.1 | ubiquitin-conjugating enzyme E2, putative |
Leishmania infantum | LinJ.02.0360 | ubiquitin-conjugating enzyme e2, putative |
Leishmania major | LmjF.02.0390 | ubiquitin-conjugating enzyme e2, putative |
Leishmania mexicana | LmxM.02.0390 | ubiquitin-conjugating enzyme e2, putative |
Loa Loa (eye worm) | LOAG_05393 | ube2i2 protein |
Mus musculus | 22196 | ubiquitin-conjugating enzyme E2I |
Mus musculus | 102641751 | SUMO-conjugating enzyme UBC9-like |
Neospora caninum | NCLIV_003300 | Ubiquitin carrier protein (EC 6.3.2.-), related |
Oryza sativa | 4331446 | Os03g0123100 |
Oryza sativa | 4349236 | Os10g0536000 |
Plasmodium berghei | PBANKA_0816100 | SUMO-conjugating enzyme UBC9, putative |
Plasmodium falciparum | PF3D7_0915100 | SUMO-conjugating enzyme UBC9 |
Plasmodium knowlesi | PKNH_0713100 | SUMO-conjugating enzyme UBC9, putative |
Plasmodium vivax | PVX_099185 | SUMO-conjugating enzyme UBC9, putative |
Saccharomyces cerevisiae | YDL064W | E2 SUMO-conjugating protein UBC9 |
Schistosoma japonicum | Sjp_0079040 | ko:K10577 ubiquitin-conjugating enzyme E2 I, putative |
Schistosoma mansoni | Smp_103710 | ubiquitin-conjugating enzyme E2 I |
Schmidtea mediterranea | mk4.028470.00 | SUMO-conjugating enzyme UBC9 |
Schmidtea mediterranea | mk4.001799.00 | SUMO-conjugating enzyme UBC9 |
Trypanosoma brucei gambiense | Tbg.972.2.1030 | ubiquitin-conjugating enzyme e2, putative |
Trypanosoma brucei | Tb927.2.2460 | ubiquitin-conjugating enzyme E2, putative |
Trypanosoma cruzi | TcCLB.503515.14 | ubiquitin-conjugating enzyme E2, putative |
Trypanosoma cruzi | TcCLB.508741.280 | ubiquitin-conjugating enzyme E2, putative |
Toxoplasma gondii | TGME49_208780 | ubiquitin-conjugating enzyme subfamily protein |
Theileria parva | TP03_0540 | ubiquitin-conjugating enzyme, putative |
Trichomonas vaginalis | TVAG_050270 | ubiquitin-conjugating enzyme rad6, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.2460 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.2460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.2460 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.2460 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F29B9.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F29B9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F29B9.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F29B9.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F29B9.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F29B9.6 | Caenorhabditis elegans | sterile | wormbase |
YDL064W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0816100 | Plasmodium berghei | Essential | plasmo |
TGME49_208780 this record | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ubiquitin-conjugating enzyme E2I | Compounds | References |
1 literature reference was collected for this gene.