pI: 6.1515 |
Length (AA): 1370 |
MW (Da): 159972 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 14 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
23 | 433 | 1wa5 (B) | 88 | 513 | 8.00 | 0.000044 | 0.08 | 0.29 | -0.33 |
24 | 1127 | 1u6g (C) | 8 | 1203 | 10.00 | 0 | 1 | 0.54 | 0.43 |
8 | 173 | 4hmy (A) | 15 | 174 | 14.00 | 0.00029 | 0.86 | 0.321968 | -0.35 |
26 | 232 | 4hmy (B) | 17 | 217 | 23.00 | 0 | 0.96 | 0.412395 | 0.02 |
100 | 279 | 4hmy (A) | 101 | 283 | 19.00 | 0.27 | 0.93 | 0.391687 | -0.5 |
551 | 707 | 4v3d (A) | 528 | 693 | 30.00 | 0.12 | 0.55 | 0.163099 | 1.14 |
867 | 1050 | 4tql (A) | 27 | 213 | 13.00 | 0.41 | 0.07 | 0.285107 | -0.64 |
8 | 173 | 4hmy (A) | 15 | 174 | 14.00 | 0.00072 | 0.84 | 0.322282 | -0.45 |
18 | 1063 | 4rh7 (A) | 1255 | 2285 | 10.00 | 0 | 0.93 | 0.267526 | 1.24 |
23 | 130 | 4db6 (A) | 12 | 124 | 13.00 | 0.83 | 0.29 | 0.276059 | -1.15 |
489 | 973 | 2nyy (A) | 670 | 1128 | 25.00 | 0.11 | 0.93 | 0.312505 | 1.33 |
522 | 600 | 3ult (A) | 35 | 116 | 27.00 | 0.34 | 0.16 | 0.408948 | -1.09 |
552 | 708 | 4v3d (A) | 528 | 693 | 30.00 | 0.13 | 0.55 | 0.160385 | 1.14 |
1117 | 1356 | 1pzd (A) | 615 | 873 | 16.00 | 0.8 | 0.5 | 0.203876 | 0.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, Oocyst, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Female Gametocyte. | Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127619)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G31490 | coatomer subunit beta-2 |
Arabidopsis thaliana | AT4G31480 | coatomer subunit beta-1 |
Babesia bovis | BBOV_IV010410 | coatamer beta subunit, putative |
Brugia malayi | Bm1_24795 | coatomer beta subunit |
Candida albicans | CaO19.8161 | ER-Golgi transport |
Candida albicans | CaO19.528 | ER-Golgi transport |
Caenorhabditis elegans | CELE_Y25C1A.5 | Protein COPB-1 |
Cryptosporidium hominis | Chro.60040 | hypothetical protein |
Cryptosporidium parvum | cgd6_270 | hypothetical protein |
Dictyostelium discoideum | DDB_G0284735 | adaptin N-terminal domain-containing protein |
Drosophila melanogaster | Dmel_CG6223 | Coat Protein (coatomer) beta |
Echinococcus granulosus | EgrG_000777200 | Coatomer subunit beta |
Entamoeba histolytica | EHI_027720 | coatomer beta subunit, putative |
Entamoeba histolytica | EHI_088220 | coatomer beta subunit, putative |
Entamoeba histolytica | EHI_173180 | coatomer subunit beta, putative |
Echinococcus multilocularis | EmuJ_000777200 | Coatomer subunit beta |
Giardia lamblia | GL50803_88082 | Coatomer beta subunit |
Homo sapiens | ENSG00000129083 | coatomer protein complex, subunit beta 1 |
Leishmania braziliensis | LbrM.20.5560 | coatomer beta subunit, putative |
Leishmania donovani | LdBPK_201390.1 | coatomer beta subunit, putative |
Leishmania infantum | LinJ.20.1390 | coatomer beta subunit, putative |
Leishmania major | LmjF.20.1350 | coatomer beta subunit, putative |
Leishmania mexicana | LmxM.20.1350 | coatomer beta subunit, putative |
Loa Loa (eye worm) | LOAG_01407 | coatomer beta subunit |
Mus musculus | ENSMUSG00000030754 | coatomer protein complex, subunit beta 1 |
Neospora caninum | NCLIV_039080 | Adaptin N terminal region family protein, related |
Oryza sativa | 4349913 | Os11g0174000 |
Oryza sativa | 4326915 | Os01g0281400 |
Plasmodium berghei | PBANKA_1014900 | coatomer subunit beta, putative |
Plasmodium falciparum | PF3D7_1429800 | coatomer subunit beta, putative |
Plasmodium knowlesi | PKNH_1328900 | coatomer subunit beta, putative |
Plasmodium vivax | PVX_085050 | coatamer protein, beta subunit, putative |
Plasmodium yoelii | PY01272 | coatomer beta subunit |
Saccharomyces cerevisiae | YDR238C | Sec26p |
Schistosoma japonicum | Sjp_0060340 | Coatomer subunit beta, putative |
Schistosoma mansoni | Smp_124430 | coatomer beta subunit |
Schmidtea mediterranea | mk4.006851.00 | Coatomer subunit beta |
Schmidtea mediterranea | mk4.020599.00 | Coatomer subunit beta |
Trypanosoma brucei gambiense | Tbg972.1.1540 | coatomer beta subunit, putative |
Trypanosoma brucei | Tb927.1.2570 | coatomer beta subunit |
Trypanosoma congolense | TcIL3000_1_1330 | coatomer beta subunit, putative |
Trypanosoma cruzi | TcCLB.506563.30 | coatomer beta subunit, putative |
Toxoplasma gondii | TGME49_266990 | beta-COP |
Theileria parva | TP01_0687 | coatomer beta subunit, putative |
Trichomonas vaginalis | TVAG_366270 | coatomer beta subunit, putative |
Trichomonas vaginalis | TVAG_150910 | coatomer beta subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.2570 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.1.2570 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y25C1A.5 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_Y25C1A.5 | Caenorhabditis elegans | sterile | wormbase |
YDR238C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1014900 | Plasmodium berghei | Essential | plasmo |
TGME49_266990 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5