Detailed view for TGME49_286630

Basic information

TDR Targets ID: 260930
Toxoplasma gondii, redoxin domain-containing protein
Source Database / ID:  ToxoDB 

pI: 9.0049 | Length (AA): 292 | MW (Da): 31107 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08534   Redoxin

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
117 292 1nm3 (A) 5 171 47.00 0 1 1.24 -1.3
151 285 1hd2 (A) 32 160 34.00 0 1 0.92 -1.52
115 283 2wfc (A) 30 186 37.00 0 1 1.07947 -1.42
116 292 1nm3 (A) 4 171 47.00 0 1 1.21666 -1.09
118 237 4fh8 (A) 7 124 25.00 0.7 0.82 0.606359 0.06
126 161 3ggn (A) 48 82 49.00 0.85 0.17 0.365688 2.34
136 236 2zct (B) 9 127 31.00 0.091 0.36 0.51829 -0.47
154 223 4xra (A) 34 104 36.00 0.036 0.75 0.640126 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. Gregory Hehl AB Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile ME49 Oocyst. Fritz HM
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_127915)

Species Accession Gene Product
Arabidopsis thaliana AT3G52960   peroxiredoxin-2E
Arabidopsis thaliana AT1G65970   thioredoxin-dependent peroxidase 2
Arabidopsis thaliana AT1G60740   peroxiredoxin-2D
Candida albicans CaO19.8054   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.10278   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.2762   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.424   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Dictyostelium discoideum DDB_G0285741   hypothetical protein
Drosophila melanogaster Dmel_CG7217   Peroxiredoxin 5
Homo sapiens ENSG00000126432   peroxiredoxin 5
Mus musculus 54683   peroxiredoxin 5
Neospora caninum NCLIV_014020   Peroxiredoxin-2E-1 (EC 1.11.1.15), related
Oryza sativa 4341570   Os06g0625500
Oryza sativa 4328586   Os02g0192700
Oryza sativa 4325511   Os01g0675100
Plasmodium berghei PBANKA_0213300   1-cys peroxiredoxin, putative
Plasmodium falciparum PF3D7_0729200   1-cys peroxiredoxin
Plasmodium knowlesi PKNH_0213800   1-cys peroxiredoxin, putative
Plasmodium vivax PVX_081760   peroxiredoxin, putative
Plasmodium yoelii PY01475   hypothetical protein
Saccharomyces cerevisiae YLR109W   Ahp1p
Schmidtea mediterranea mk4.000295.04   Peroxiredoxin-5, mitochondrial
Toxoplasma gondii TGME49_286630   redoxin domain-containing protein

Essentiality

TGME49_286630 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0213300 Plasmodium berghei Dispensable plasmo
TGME49_286630 this record Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum 1-cys peroxiredoxin Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_286630 (Toxoplasma gondii), redoxin domain-containing protein
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