pI: 6.9789 |
Length (AA): 2657 |
MW (Da): 306807 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
35 | 352 | 3t7a (A) | 42 | 358 | 47.00 | 0 | 1 | 0.713684 | -0.56 |
515 | 571 | 1ezg (A) | 27 | 83 | 32.00 | 0.65 | 0.66 | 0.627253 | -2.64 |
1239 | 1649 | 1d2p (A) | 537 | 904 | 28.00 | 0.59 | 0.09 | 0.128886 | 1.09 |
2461 | 2569 | 3ult (A) | 6 | 114 | 28.00 | 0.00018 | 0.19 | 0.473224 | -1.39 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Oocyst. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, merozoite, sporozoite, early ring, Ring, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | early schizont, early trophozoite, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. | Otto TD Zanghi G |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_127768)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G01310 | phosphoglycerate mutase-like protein |
Arabidopsis thaliana | AT5G15070 | phosphoglycerate mutase-like protein |
Babesia bovis | BBOV_IV010350 | histidine acid phosphatase superfamily protein |
Brugia malayi | Bm1_57300 | CG14616-PC |
Candida albicans | CaO19.8595 | C terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton. |
Candida albicans | CaO19.980 | C terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton. |
Candida albicans | CaO19.5679 | N terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton. |
Caenorhabditis elegans | CELE_F46F11.1 | Protein F46F11.1, isoform A |
Cryptosporidium hominis | Chro.70177 | hypothetical protein |
Cryptosporidium parvum | cgd7_1500 | conserved protein |
Dictyostelium discoideum | DDB_G0284617 | hypothetical protein |
Drosophila melanogaster | Dmel_CG14616 | lethal (1) G0196 |
Echinococcus granulosus | EgrG_000064700 | inositol hexakisphosphate |
Echinococcus multilocularis | EmuJ_000064700 | inositol hexakisphosphate |
Giardia lamblia | GL50803_103074 | Hypothetical protein |
Homo sapiens | ENSG00000168781 | diphosphoinositol pentakisphosphate kinase 1 |
Homo sapiens | 100508782 | inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1-like |
Homo sapiens | ENSG00000145725 | diphosphoinositol pentakisphosphate kinase 2 |
Loa Loa (eye worm) | LOAG_01583 | hypothetical protein |
Mus musculus | ENSMUSG00000033526 | diphosphoinositol pentakisphosphate kinase 1 |
Mus musculus | ENSMUSG00000040648 | diphosphoinositol pentakisphosphate kinase 2 |
Neospora caninum | NCLIV_019880 | GH24076, related |
Oryza sativa | 4333768 | Os03g0689100 |
Oryza sativa | 4327902 | Os01g0777700 |
Plasmodium berghei | PBANKA_1014400 | acid phosphatase, putative |
Plasmodium falciparum | PF3D7_1430300 | acid phosphatase, putative |
Plasmodium knowlesi | PKNH_1328400 | acid phosphatase, putative |
Plasmodium vivax | PVX_085025 | hypothetical protein, conserved |
Plasmodium yoelii | PY01267 | unknown protein-related |
Saccharomyces cerevisiae | YLR410W | inositol polyphosphate kinase VIP1 |
Schistosoma japonicum | Sjp_0219600 | expressed protein |
Schistosoma japonicum | Sjp_0041140 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase, putative |
Schistosoma japonicum | Sjp_0313570 | IPR001451,Bacterial transferase hexapeptide repeat;IPR011004,Trimeric LpxA-like,domain-containing |
Schistosoma japonicum | Sjp_0041130 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, putative |
Schistosoma mansoni | Smp_045860.2 | histidine acid phosphatase |
Schistosoma mansoni | Smp_045860.1 | histidine acid phosphatase |
Schmidtea mediterranea | mk4.002166.01 | Putative histidine acid phosphatase |
Schmidtea mediterranea | mk4.004917.02 | Putative histidine acid phosphatase |
Toxoplasma gondii | TGME49_304650 | histidine acid phosphatase superfamily protein |
Theileria parva | TP01_0694 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1014400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_304650 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.