Detailed view for TGME49_251760

Basic information

TDR Targets ID: 261331
Toxoplasma gondii, subunit of proteaseome activator complex, putative
Source Database / ID:  ToxoDB 

pI: 6.9555 | Length (AA): 269 | MW (Da): 30711 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02252   Proteasome activator pa28 beta subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0008537   proteasome activator complex  
GO:0008538   proteasome activator activity  

Metabolic Pathways

Proteasome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
122 259 1avo (B) 104 241 38.00 0 1 1.10921 -1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_131194)

Species Accession Gene Product
Babesia bovis BBOV_II005350   subunit of proteaseome activator complex, putative
Brugia malayi Bm1_29835   Proteasome activator pa28 beta subunit family protein
Caenorhabditis elegans CELE_Y66D12A.9   Protein Y66D12A.9
Cryptosporidium hominis Chro.80360   subunit of proteaseome activator complex
Cryptosporidium parvum cgd8_3090   proteasome activator p28/ Ki autoantigen
Dictyostelium discoideum DDB_G0285099   proteasome activator 28 subunit
Drosophila melanogaster Dmel_CG1591   CG1591 gene product from transcript CG1591-RB
Echinococcus granulosus EgrG_000380200   proteasome activator complex subunit 3
Echinococcus granulosus EgrG_000544000   Proteasome activator pa28 REG alpha beta subunit
Echinococcus multilocularis EmuJ_000380200   proteasome activator complex subunit 3
Echinococcus multilocularis EmuJ_000544000   Proteasome activator pa28, REG alpha beta subunit
Homo sapiens ENSG00000131467   proteasome (prosome, macropain) activator subunit 3 (PA28 gamma
Loa Loa (eye worm) LOAG_03437   proteasome activator pa28 beta subunit family protein
Mus musculus ENSMUSG00000078652   proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Neospora caninum NCLIV_066820   proteasome activator subunit, putative
Plasmodium berghei PBANKA_0809100   proteasome activator 28 subunit beta, putative
Plasmodium falciparum PF3D7_0907700   proteasome activator 28 subunit beta, putative
Plasmodium knowlesi PKNH_0705500   proteasome activator 28 subunit beta, putative
Plasmodium vivax PVX_098830   subunit of proteaseome activator complex, putative
Plasmodium yoelii PY04117   Proteasome activator pa28 beta subunit, putative
Schistosoma japonicum Sjp_0201210   ko:K06698 proteasome activator subunit 3 (PA28 gamma), putative
Schistosoma mansoni Smp_017660   proteasome subunit
Schmidtea mediterranea mk4.000468.00   Proteasome activator PA28-gamma
Schmidtea mediterranea mk4.015223.00   Proteasome activator PA28-gamma
Schmidtea mediterranea mk4.003007.00   Proteasome activator PA28-gamma
Schmidtea mediterranea mk4.000196.00   Proteasome activator PA28-gamma
Toxoplasma gondii TGME49_251760   subunit of proteaseome activator complex, putative
Theileria parva TP02_0839   proteasome activator complex subunit, putative

Essentiality

TGME49_251760 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0809100 Plasmodium berghei Slow plasmo
TGME49_251760 this record Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_251760 (Toxoplasma gondii), subunit of proteaseome activator complex, putative
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