pI: 8.377 |
Length (AA): 641 |
MW (Da): 70442 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
467 | 623 | 3o2u (A) | 1005 | 1156 | 23.00 | 0 | 1 | 0.45743 | -0.16 |
485 | 612 | 2h2y (A) | 8 | 135 | 54.00 | 0 | 1 | 0.940188 | -1.46 |
501 | 609 | 2r0j (A) | 5 | 112 | 34.00 | 0 | 1 | 0.747747 | -1.61 |
525 | 609 | 2gjd (A) | 37 | 122 | 34.00 | 0.00000001 | 1 | 0.568305 | -0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128794)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G75440 | putative ubiquitin-conjugating enzyme E2 16 |
Arabidopsis thaliana | AT1G45050 | ubiquitin-conjugating enzyme 15 |
Arabidopsis thaliana | AT5G42990 | ubiquitin-conjugating enzyme 18 |
Babesia bovis | BBOV_II006740 | ubiquitin-conjugating enzyme E2 |
Brugia malayi | Bm1_47885 | ubiquitin-conjugating enzyme UBC2-1 - Arabidopsis thaliana |
Candida albicans | CaO19.12797 | ubiquitin-conjugating enzyme |
Candida albicans | CaO19.5337 | ubiquitin-conjugating enzyme |
Caenorhabditis elegans | CELE_Y54E5B.4 | Protein UBC-16 |
Dictyostelium discoideum | DDB_G0268938 | ubiquitin-conjugating enzyme E2W |
Drosophila melanogaster | Dmel_CG7220 | CG7220 gene product from transcript CG7220-RA |
Homo sapiens | ENSG00000104343 | ubiquitin-conjugating enzyme E2W (putative) |
Loa Loa (eye worm) | LOAG_02096 | hypothetical protein |
Mus musculus | ENSMUSG00000025939 | ubiquitin-conjugating enzyme E2W (putative) |
Neospora caninum | NCLIV_027420 | hypothetical protein |
Neospora caninum | NCLIV_001990 | Ubiquitin carrier protein (EC 6.3.2.-), related |
Oryza sativa | 4333728 | Os03g0681400 |
Oryza sativa | 4352894 | Os12g0636800 |
Plasmodium berghei | PBANKA_1358400 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium berghei | PBANKA_1029700 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium falciparum | PF3D7_1345500 | ubiquitin-conjugating enzyme E2 |
Plasmodium falciparum | PF3D7_1412900 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium knowlesi | PKNH_1255800 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium knowlesi | PKNH_1345400 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium vivax | PVX_083175 | ubiquitin-conjugating enzyme E2, putative |
Plasmodium vivax | PVX_085810 | ubiquitin-conjugating enzyme, putative |
Plasmodium yoelii | PY05644 | putative ubiquitin-conjugating enzyme 16 |
Plasmodium yoelii | PY00590 | putative ubiquitin-conjugating enzyme 16 |
Toxoplasma gondii | TGME49_259090 | ubiquitin-conjugating enzyme subfamily protein |
Toxoplasma gondii | TGME49_295990 | ubiquitin conjugating enzyme E2, putative |
Theileria parva | TP02_0640 | ubiquitin-protein ligase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1029700 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1358400 | Plasmodium berghei | Essential | plasmo |
TGME49_295990 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_259090 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_295990 this record | Toxoplasma gondii | Probably essential | sidik |
TGME49_259090 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.