Detailed view for TGME49_213730

Basic information

TDR Targets ID: 261582
Toxoplasma gondii, lanthionine synthetase C family protein
Source Database / ID:  ToxoDB 

pI: 8.2183 | Length (AA): 424 | MW (Da): 46400 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05147   Lanthionine synthetase C-like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 421 2g0d (A) 8 409 16.00 0 1 1.03 -1.07
42 421 2g0d (A) 9 409 15.00 0 1 1 -1.1
7 422 3e6u (A) 1 399 33.00 0 1 1.39663 -0.73
32 422 3e6u (A) 29 399 37.00 0 1 1.40197 -0.88
68 422 3t33 (A) 75 410 38.00 0 1 1.27606 -0.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. Gregory Fritz HM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 merozoite, ME49 Bradyzoite. Hehl AB Sibley/Greg
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Sibley/Greg ToxoDB
  • Gregory ToxoDB

Orthologs

Ortholog group members (OG5_128365)

Species Accession Gene Product
Arabidopsis thaliana AT1G52920   G-protein coupled receptor 2
Arabidopsis thaliana AT2G20770   protein GCR2-LIKE 2
Brugia malayi Bm1_38165   Lanthionine synthetase C-like protein
Drosophila melanogaster Dmel_CG2061   CG2061 gene product from transcript CG2061-RD
Echinococcus granulosus EgrG_000611700   Lancl1 protein
Echinococcus granulosus EgrG_001073250   lanc protein
Echinococcus multilocularis EmuJ_000611700   Lancl1 protein
Echinococcus multilocularis EmuJ_001073250   lanc protein
Homo sapiens ENSG00000132434   LanC lantibiotic synthetase component C-like 2 (bacterial)
Homo sapiens ENSG00000115365   LanC lantibiotic synthetase component C-like 1 (bacterial)
Homo sapiens ENSG00000147036   LanC lantibiotic synthetase component C-like 3 (bacterial)
Loa Loa (eye worm) LOAG_02178   hypothetical protein
Loa Loa (eye worm) LOAG_02179   hypothetical protein
Mus musculus ENSMUSG00000026000   LanC (bacterial lantibiotic synthetase component C)-like 1
Mus musculus ENSMUSG00000047344   LanC lantibiotic synthetase component C-like 3 (bacterial)
Mus musculus 71835   LanC (bacterial lantibiotic synthetase component C)-like 2
Neospora caninum NCLIV_013460   hypothetical protein
Oryza sativa 4349013   Os10g0497900
Oryza sativa 9267565   Os04g0529600
Plasmodium berghei PBANKA_1240200   G-protein coupled receptor, putative
Plasmodium falciparum PF3D7_0525400   G-protein coupled receptor, putative
Plasmodium knowlesi PKNH_1007400   G-protein coupled receptor, putative
Plasmodium vivax PVX_079975   G-protein coupled receptor, putative
Plasmodium yoelii PY02110   similar to TASP for testis-specific adriamycin sensitivity protein-related
Schistosoma japonicum Sjp_0055200   LanC-like protein 1, putative
Schistosoma mansoni Smp_118820   lanc-like protein
Schmidtea mediterranea mk4.010484.00  
Schmidtea mediterranea mk4.025855.00  
Schmidtea mediterranea mk4.005420.06  
Toxoplasma gondii TGME49_213730   lanthionine synthetase C family protein

Essentiality

TGME49_213730 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1240200 Plasmodium berghei Dispensable plasmo
TGME49_213730 this record Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens LanC lantibiotic synthetase component C-like 2 (bacterial) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_213730 (Toxoplasma gondii), lanthionine synthetase C family protein
Title for this comment
Comment