pI: 11.1019 |
Length (AA): 140 |
MW (Da): 15617 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
85 | 140 | 1hdj () | 2 | 60 | 27.00 | 0 | 1 | 0.88 | -1.76 |
86 | 140 | 2cug (A) | 18 | 75 | 27.00 | 0 | 1 | 0.89 | -1.93 |
77 | 140 | 2guz (A) | 103 | 167 | 53.00 | 0 | 1 | 1.29584 | -2.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127641)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G35795 | mitochondrial import inner membrane translocase subunit TIM14-1 |
Arabidopsis thaliana | AT3G09700 | chaperone DnaJ-domain containing protein |
Arabidopsis thaliana | AT5G03030 | chaperone DnaJ-domain containing protein |
Babesia bovis | BBOV_III008010 | conserved hypothetical protein |
Brugia malayi | Bm1_43705 | Hypothetical 16.5 kDa protein in PAS8-EGT2 intergenic region |
Candida albicans | CaO19.11667 | similar to S. cerevisiae PAM18 (YLR008C) DnaJ-like mitochondrial import motor component |
Candida albicans | CaO19.4190 | similar to S. cerevisiae PAM18 (YLR008C) DnaJ-like mitochondrial import motor component |
Caenorhabditis elegans | CELE_T19B4.4 | Protein DNJ-21 |
Cryptosporidium hominis | Chro.50020 | chaperone |
Cryptosporidium parvum | cgd5_3520 | chaperoneDNAj domain protein chaperone |
Dictyostelium discoideum | DDB_G0283735 | mitochondrial import inner membrane translocase subunit 14 |
Drosophila melanogaster | Dmel_CG7394 | CG7394 gene product from transcript CG7394-RD |
Echinococcus granulosus | EgrG_000380800 | Heat shock protein DnaJ N terminal |
Echinococcus multilocularis | EmuJ_000380800 | Heat shock protein DnaJ, N terminal |
Homo sapiens | ENSG00000205981 | DnaJ (Hsp40) homolog, subfamily C, member 19 |
Homo sapiens | 29103 | DnaJ (Hsp40) homolog, subfamily C, member 15 |
Leishmania braziliensis | LbrM.24.1990 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_241990.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.24.1990 | hypothetical protein, conserved |
Leishmania major | LmjF.24.1910 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.24.1910 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03592 | DnaJ domain-containing protein |
Mus musculus | ENSMUSG00000022013 | DnaJ (Hsp40) homolog, subfamily C, member 15 |
Mus musculus | ENSMUSG00000027679 | DnaJ (Hsp40) homolog, subfamily C, member 19 |
Neospora caninum | NCLIV_022100 | DnaJ domain containing protein, related |
Oryza sativa | 4334293 | Os03g0776900 |
Oryza sativa | 4324086 | Os01g0157800 |
Oryza sativa | 4342627 | Os07g0192300 |
Plasmodium berghei | PBANKA_0621900 | mitochondrial import inner membrane translocase subunit TIM14, putative |
Plasmodium falciparum | PF3D7_0724400 | mitochondrial import inner membrane translocase subunit TIM14, putative |
Plasmodium knowlesi | PKNH_0319800 | mitochondrial import inner membrane translocase subunit TIM14, putative |
Plasmodium vivax | PVX_096125 | mitochondrial import inner membrane translocase subunit TIM14, putative |
Plasmodium yoelii | PY01612 | hypothetical protein |
Saccharomyces cerevisiae | YLR008C | Pam18p |
Schistosoma japonicum | Sjp_0210800 | ko:K09535 DnaJ homolog, subfamily C, member 15, putative |
Schistosoma mansoni | Smp_151650 | hypothetical protein |
Schmidtea mediterranea | mk4.001165.01 | |
Trypanosoma brucei gambiense | Tbg972.8.6370 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.6310 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_8_6170 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511903.270 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503885.70 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_202810 | TIM14 |
Theileria parva | TP02_0356 | dnaJ protein, putative |
Trichomonas vaginalis | TVAG_436580 | S.cerevisiae chromosome XII reading frame orf ylr008c, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6310 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6310 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6310 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6310 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T19B4.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T19B4.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T19B4.4 | Caenorhabditis elegans | sterile | wormbase |
YLR008C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_202810 this record | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.