Detailed view for TGME49_270560

Basic information

TDR Targets ID: 262022
Toxoplasma gondii, peptidyl-prolyl cis-trans isomerase family 1
Source Database / ID:  ToxoDB 

pI: 7.3238 | Length (AA): 195 | MW (Da): 20859 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 195 1ihg (A) 2 188 40.00 0 1 1.38 -0.62
40 190 2b71 (A) 41 191 63.00 0 1 1.65 -1.58
21 188 2k7n (A) 2 162 63.00 0 1 1.62174 -0.79
39 190 2b71 (A) 40 191 62.00 0 1 1.63519 -1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 merozoite, ME49 Bradyzoite. Hehl AB Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. Gregory Fritz HM
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_127991)

Species Accession Gene Product
Arabidopsis thaliana AT2G36130   peptidyl-prolyl cis-trans isomerase-like 1
Brugia malayi Bm1_08840   cyclophilin-type peptidyl-prolyl cis-trans isomerase-12, Bmcyp-12
Candida albicans CaO19.1552   likely Cyclophilin type peptidyl-prolyl cis-trans isomerase similar to C. albicans CYP1 (CaP19.6472) and to S. cerevisiae CPR3 (
Candida albicans CaO19.9126   likely Cyclophilin type peptidyl-prolyl cis-trans isomerase similar to C. albicans CYP1 (CaP19.6472) and to S. cerevisiae CPR3 (
Caenorhabditis elegans CELE_C34D4.12   Protein CYN-12
Dictyostelium discoideum DDB_G0269216   cyclophilin-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG13892   Cyclophilin-like
Escherichia coli b3363   peptidyl-prolyl cis-trans isomerase A (rotamase A)
Echinococcus granulosus EgrG_000992200   peptidyl prolyl cis trans isomerase 1
Echinococcus multilocularis EmuJ_000992200   peptidyl prolyl cis trans isomerase 1
Giardia lamblia GL50803_17000   Peptidyl-prolyl cis-trans isomerase B precursor
Homo sapiens ENSG00000137168   peptidylprolyl isomerase (cyclophilin)-like 1
Loa Loa (eye worm) LOAG_10735   hypothetical protein
Mus musculus ENSMUSG00000024007   peptidylprolyl isomerase (cyclophilin)-like 1
Neospora caninum NCLIV_036200   cyclophilin, putative
Oryza sativa 4346316   Os08g0559400
Plasmodium berghei PBANKA_1243300   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium falciparum PF3D7_0528700   peptidyl-prolyl cis-trans isomerase
Plasmodium knowlesi PKNH_1004000   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium vivax PVX_079815   cyclophilin, putative
Plasmodium yoelii PY00693   cyclophilin-like protein
Saccharomyces cerevisiae YML078W   peptidylprolyl isomerase CPR3
Schistosoma japonicum Sjp_0017950   ko:K01802 peptidylprolyl isomerase [EC5.2.1.8], putative
Schistosoma mansoni Smp_029900.1   peptidyl-prolyl cis-trans isomerase-like 1 ppil1
Schistosoma mansoni Smp_029900.2   peptidyl-prolyl cis-trans isomerase-like 1 ppil1
Schmidtea mediterranea mk4.007070.00   Peptidyl-prolyl cis-trans isomerase-like 1
Toxoplasma gondii TGME49_270560   peptidyl-prolyl cis-trans isomerase family 1

Essentiality

TGME49_270560 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
b3363 Escherichia coli non-essential goodall
CELE_C34D4.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_C34D4.12 Caenorhabditis elegans larval arrest wormbase
CELE_C34D4.12 Caenorhabditis elegans sterile wormbase
TGME49_270560 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_270560 (Toxoplasma gondii), peptidyl-prolyl cis-trans isomerase family 1
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