pI: 11.3063 |
Length (AA): 468 |
MW (Da): 52052 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
223 | 423 | 5cwm (A) | 23 | 225 | 28.00 | 0.12 | 0.77 | 0.766687 | -0.94 |
260 | 468 | 1ge9 (A) | 1 | 184 | 30.00 | 0 | 1 | 0.730581 | -0.37 |
265 | 467 | 1dd5 (A) | 3 | 184 | 27.00 | 0 | 1 | 0.748761 | -0.78 |
265 | 468 | 1is1 (A) | 3 | 185 | 34.00 | 0 | 1 | 0.804697 | -0.76 |
355 | 468 | 3lf9 (A) | 1 | 113 | 28.00 | 0.00000000014 | 0.99 | 0.75859 | -1.59 |
388 | 449 | 5jsn (B) | 38 | 99 | 32.00 | 0.92 | 0.89 | 0.550679 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Ortholog group members (OG5_127647)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G01800 | ribosome recycling factor |
Arabidopsis thaliana | AT3G63190 | ribosome-recycling factor |
Brugia malayi | Bm1_29280 | ribosome recycling factor family protein |
Candida albicans | CaO19.477 | similar to S. cerevisiae RRF1 (YHR038W) mitochondrial translation termination and ribosome recycling factor |
Candida albicans | CaO19.8108 | similar to S. cerevisiae RRF1 (YHR038W) mitochondrial translation termination and ribosome recycling factor |
Caenorhabditis elegans | CELE_T20F5.3 | Protein MRRF-1 |
Chlamydia trachomatis | CT_677 | ribosome-recycling factor |
Dictyostelium discoideum | DDB_G0268518 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4447 | CG4447 gene product from transcript CG4447-RA |
Escherichia coli | b0172 | ribosome recycling factor |
Homo sapiens | ENSG00000148187 | mitochondrial ribosome recycling factor |
Loa Loa (eye worm) | LOAG_05261 | ribosome recycling factor family protein |
Mycobacterium leprae | ML1590c | RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF) |
Mus musculus | ENSMUSG00000026887 | mitochondrial ribosome recycling factor |
Mycobacterium tuberculosis | Rv2882c | Ribosome recycling factor Frr (ribosome releasing factor) (RRF) |
Mycobacterium ulcerans | MUL_2075 | ribosome recycling factor |
Neospora caninum | NCLIV_028380 | hypothetical protein, conserved |
Oryza sativa | 4336241 | Os04g0490400 |
Oryza sativa | 4343662 | Os07g0570700 |
Saccharomyces cerevisiae | YHR038W | Rrf1p |
Toxoplasma gondii | TGME49_257980 | ribosome recycling factor protein |
Treponema pallidum | TP0604 | ribosome recycling factor |
Wolbachia endosymbiont of Brugia malayi | Wbm0805 | ribosome recycling factor |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2929 | Mycobacterium tuberculosis | essential | nmpdr |
b0172 | Escherichia coli | essential | goodall |
TGME49_257980 this record | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.