Detailed view for TGME49_301370

Basic information

TDR Targets ID: 262055
Toxoplasma gondii, DHHC zinc finger domain-containing protein
Source Database / ID:  ToxoDB 

pI: 8.3892 | Length (AA): 278 | MW (Da): 31731 | Paralog Number: 3

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01529   DHHC palmitoyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
216 264 1mg5 (A) 109 151 40.00 0.98 0.18 0.320559 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile VEG Tachyzoite. Gregory
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile ME49 merozoite. Hehl AB
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB

Orthologs

Ortholog group members (OG5_126830)

Species Accession Gene Product
Arabidopsis thaliana AT4G22750   DHHC-type zinc finger family protein
Arabidopsis thaliana AT4G22753   sterol 4-alpha methyl oxidase 1-3
Arabidopsis thaliana AT4G00840   putative S-acyltransferase
Arabidopsis thaliana AT3G60800   DHHC-type zinc finger family protein
Babesia bovis BBOV_I002780   DHHC zinc finger domain containing protein
Babesia bovis BBOV_III005080   DHHC zinc finger domain containing protein
Babesia bovis BBOV_II001940   conserved hypothetical protein
Brugia malayi Bm1_47340   Zinc finger DHHC domain containing protein 2
Candida albicans CaO19.6802   potential integral membrane protein
Candida albicans CaO19.14094   potential integral membrane protein
Caenorhabditis elegans CELE_ZK757.4a   Protein DHHC-4, isoform D
Caenorhabditis elegans CELE_ZK757.4   Protein DHHC-4, isoform C
Cryptosporidium hominis Chro.10160   cell cycle regulator with zn-finger domain
Cryptosporidium hominis Chro.60520   DHHC zinc finger multi-pass transmembrane protein
Cryptosporidium hominis Chro.80577   hypothetical protein
Cryptosporidium parvum cgd1_1380   DHHC family palmitoyl transferases with a signal peptide and 4x transmembrane domains
Cryptosporidium parvum cgd6_4540   DHHC family palmitoyl transferase
Cryptosporidium parvum cgd8_5050   hypothetical protein
Dictyostelium discoideum DDB_G0278239   hypothetical protein
Dictyostelium discoideum DDB_G0274739   hypothetical protein
Drosophila melanogaster Dmel_CG1407   CG1407 gene product from transcript CG1407-RB
Drosophila melanogaster Dmel_CG17287   CG17287 gene product from transcript CG17287-RA
Echinococcus granulosus EgrG_001200400   palmitoyltransferase ZDHHC20
Entamoeba histolytica EHI_007270   hypothetical protein, conserved domain containing
Entamoeba histolytica EHI_004220   hypothetical protein, conserved domain containing
Entamoeba histolytica EHI_148370   hypothetical protein, conserved domain containing
Echinococcus multilocularis EmuJ_001200400   palmitoyltransferase ZDHHC20
Giardia lamblia GL50803_16928   Zinc finger domain
Homo sapiens ENSG00000102383   zinc finger, DHHC-type containing 15
Homo sapiens ENSG00000180776   zinc finger, DHHC-type containing 20
Leishmania braziliensis LbrM.23.1540   hypothetical protein, conserved
Leishmania major LmjF.23.1420   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05237   hypothetical protein
Loa Loa (eye worm) LOAG_07103   hypothetical protein
Mus musculus ENSMUSG00000021969   zinc finger, DHHC domain containing 20
Mus musculus ENSMUSG00000033906   zinc finger, DHHC domain containing 15
Neospora caninum NCLIV_067160   hypothetical protein
Neospora caninum NCLIV_066400   Os02g0819100 protein, related
Oryza sativa 4327508   Os01g0844400
Oryza sativa 4334485   Os03g0804300
Oryza sativa 4338999   Os05g0458000
Plasmodium berghei PBANKA_0108300   palmitoyltransferase DHHC2
Plasmodium berghei PBANKA_0512000   palmitoyltransferase DHHC10, putative
Plasmodium berghei PBANKA_1243000   palmitoyltransferase DHHC7
Plasmodium falciparum PF3D7_0609800   palmitoyltransferase DHHC2, putative
Plasmodium falciparum PF3D7_0528400   palmitoyltransferase DHHC7
Plasmodium falciparum PF3D7_1027900   palmitoyltransferase DHHC10, putative
Plasmodium knowlesi PKNH_1140400   palmitoyltransferase DHHC2, putative
Plasmodium knowlesi PKNH_0612300   palmitoyltransferase DHHC10, putative
Plasmodium knowlesi PKNH_1004300   palmitoyltransferase DHHC7, putative
Plasmodium vivax PVX_111325   palmitoyltransferase, putative
Plasmodium vivax PVX_079830   palmitoyltransferase, putative
Plasmodium vivax PVX_113640   palmitoyltransferase, putative
Plasmodium yoelii PY06597   DHHC zinc finger domain, putative
Plasmodium yoelii PY05972   Mus musculus RIKEN cDNA 5033406L14 gene-related
Plasmodium yoelii PY01955   DHHC zinc finger domain, putative
Saccharomyces cerevisiae YNL326C   Pfa3p
Schistosoma japonicum Sjp_0072840   Palmitoyltransferase ZDHHC2, putative
Schistosoma japonicum Sjp_0202260   Palmitoyltransferase ZDHHC15, putative
Schistosoma mansoni Smp_074930   zinc finger protein
Schistosoma mansoni Smp_169610   zinc finger protein
Schmidtea mediterranea mk4.001828.04  
Schmidtea mediterranea mk4.029211.00   Palmitoyltransferase
Trypanosoma cruzi TcCLB.509769.36   palmitoyl acyltransferase 12, putative
Toxoplasma gondii TGME49_278850   DHHC zinc finger domain-containing protein
Toxoplasma gondii TGME49_301370   DHHC zinc finger domain-containing protein
Toxoplasma gondii TGME49_250870   DHHC zinc finger domain-containing protein
Toxoplasma gondii TGME49_252200   cell cycle regulator with zn-finger domain-containing protein
Theileria parva TP02_0446   hypothetical protein
Theileria parva TP04_0326   hypothetical protein, conserved
Trichomonas vaginalis TVAG_382560   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_059570   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_224380   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_244250   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_350870   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_174160   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_392200   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_178280   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_025040   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_354850   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_119850   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_454020   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_417920   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_317570   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_098280   conserved hypothetical protein
Trichomonas vaginalis TVAG_074330   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_391910   conserved hypothetical protein
Trichomonas vaginalis TVAG_157950   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_491690   conserved hypothetical protein
Trichomonas vaginalis TVAG_004650   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_299560   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_210550   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_272340   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_181290   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_483450   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_003340   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_258210   zinc finger protein DHHC domain containing protein, putative
Trichomonas vaginalis TVAG_115670   conserved hypothetical protein
Trichomonas vaginalis TVAG_349350   zinc finger protein DHHC domain containing protein, putative

Essentiality

TGME49_301370 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1243000 Plasmodium berghei Essential plasmo
TGME49_250870 Toxoplasma gondii Probably non-essential sidik
TGME49_252200 Toxoplasma gondii Probably non-essential sidik
TGME49_278850 Toxoplasma gondii Probably non-essential sidik
TGME49_301370 this record Toxoplasma gondii Probably non-essential sidik
TGME49_250870 Toxoplasma gondii Probably essential sidik
TGME49_252200 Toxoplasma gondii Probably essential sidik
TGME49_278850 Toxoplasma gondii Probably essential sidik
TGME49_301370 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_301370 (Toxoplasma gondii), DHHC zinc finger domain-containing protein
Title for this comment
Comment