pI: 7.1805 |
Length (AA): 1196 |
MW (Da): 127473 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
92 | 689 | 2xr1 (A) | 70 | 604 | 19.00 | 0.00077 | 0.77 | 0.4073 | 1.11 |
233 | 719 | 2xr1 (A) | 215 | 636 | 26.00 | 0 | 1 | 0.327791 | 1.02 |
400 | 720 | 2i7v (A) | 132 | 457 | 35.00 | 0 | 1 | 0.597995 | -0.25 |
921 | 969 | 2k3n (A) | 3 | 51 | 45.00 | 0.2 | 0.15 | 0.45447 | 0.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_130170)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G01730 | cleavage and polyadenylation specificity factor subunit 3-II |
Babesia bovis | BBOV_I003240 | RNA-metabolising metallo-beta-lactamase and metallo-beta-lactamase superfamily domain containing protein |
Brugia malayi | Bm1_54785 | RNA-metabolising metallo-beta-lactamase family protein |
Brugia malayi | Bm1_01385 | hypothetical protein |
Caenorhabditis elegans | CELE_F10B5.8 | Protein F10B5.8 |
Cryptosporidium hominis | Chro.50268 | ENSANGP00000013258 |
Cryptosporidium parvum | cgd5_1170 | CPSF metallobeta-lactamase |
Dictyostelium discoideum | DDB_G0278189 | RNA-metabolising metallo-beta-lactamase domain-containing protein |
Drosophila melanogaster | Dmel_CG1972 | Integrator 11 |
Echinococcus granulosus | EgrG_000988200 | integrator complex subunit 11 |
Echinococcus multilocularis | EmuJ_000988200 | integrator complex subunit 11 |
Homo sapiens | ENSG00000127054 | cleavage and polyadenylation specific factor 3-like |
Loa Loa (eye worm) | LOAG_08217 | RNA-metabolising metallo-beta-lactamase |
Mus musculus | ENSMUSG00000029034 | cleavage and polyadenylation specific factor 3-like |
Oryza sativa | 4346985 | Os09g0397900 |
Onchocerca volvulus | OVOC11891 | Integrator complex subunit 11 homolog |
Plasmodium berghei | PBANKA_0806600 | cleavage and polyadenylation specificity factor, putative |
Plasmodium falciparum | PF3D7_0318600 | cleavage and polyadenylation specificity factor, putative |
Plasmodium knowlesi | PKNH_0822800 | cleavage and polyadenylation specificity factor, putative |
Plasmodium vivax | PVX_095300 | RNA-metabolising metallo-beta-lactamase domain containing protein |
Plasmodium yoelii | PY00757 | hypothetical protein |
Schistosoma japonicum | Sjp_0083750 | ko:K01172 cleavage and polyadenylation specific factor 3-like [EC:3.1.27.-], putative |
Schistosoma mansoni | Smp_073830 | cleavage and polyadenylation specificity factor |
Schmidtea mediterranea | mk4.002520.03 | |
Schmidtea mediterranea | mk4.050404.00 | |
Toxoplasma gondii | TGME49_305640 | metallo-beta-lactamase domain-containing protein |
Theileria parva | TP03_0171 | hypothetical protein |
Trichomonas vaginalis | TVAG_183200 | cleavage and polyadenylation specificity factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F10B5.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0806600 | Plasmodium berghei | Slow | plasmo |
TGME49_305640 this record | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3