pI: 6.4246 |
Length (AA): 565 |
MW (Da): 63343 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 121 | 1elw (A) | 2 | 118 | 44.00 | 0 | 1 | 0.83938 | -1.48 |
54 | 562 | 4pjw (A) | 329 | 877 | 13.00 | 0 | 1 | 0.865185 | 0.9 |
242 | 368 | 1elr (A) | 223 | 349 | 35.00 | 0 | 1 | 0.780079 | -1.61 |
373 | 486 | 4gco (A) | 137 | 250 | 49.00 | 0 | 1 | 0.92777 | -1.47 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_128289)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G62740 | carboxylate clamp-tetratricopeptide repeat protein HOP2 |
Arabidopsis thaliana | AT4G12400 | carboxylate clamp-tetratricopeptide repeat protein |
Arabidopsis thaliana | AT1G12270 | protein HOP1 |
Babesia bovis | BBOV_III002230 | tetratricopeptide repeat domain containing protein |
Brugia malayi | Bm1_55560 | TPR Domain |
Candida albicans | CaO19.3191 | co-chaperonin STI1-like orf, has 9 TPR repeats |
Candida albicans | CaO19.10702 | co-chaperonin STI1-like orf, has 9 TPR repeats |
Candida albicans | CaO19.3192 | see CaP19.3191 |
Caenorhabditis elegans | CELE_R09E12.3 | Protein STI-1 |
Cryptosporidium hominis | Chro.20201 | stress-induced protein sti1-like protein |
Cryptosporidium parvum | cgd2_1850 | stress-induced protein sti1-like protein, putative |
Dictyostelium discoideum | DDB_G0292404 | stress-induced-phosphoprotein 1 |
Drosophila melanogaster | Dmel_CG2720 | Hsp70/Hsp90 organizing protein homolog |
Echinococcus granulosus | EgrG_000264900 | stress induced phosphoprotein 1 |
Entamoeba histolytica | EHI_023300 | TPR repeat protein |
Echinococcus multilocularis | EmuJ_000264900 | stress induced phosphoprotein 1 |
Giardia lamblia | GL50803_27310 | Stress-induced-phosphoprotein 1 |
Homo sapiens | ENSG00000168439 | stress-induced phosphoprotein 1 |
Leishmania braziliensis | LbrM.08.0880 | stress-induced protein sti1 |
Leishmania donovani | LdBPK_081020.1 | stress-induced protein sti1 |
Leishmania infantum | LinJ.08.1020 | stress-induced protein sti1 |
Leishmania major | LmjF.08.1110 | stress-induced protein sti1 |
Leishmania mexicana | LmxM.08.1110 | stress-induced protein sti1 |
Loa Loa (eye worm) | LOAG_08731 | TPR domain-containing protein |
Mus musculus | ENSMUSG00000024966 | stress-induced phosphoprotein 1 |
Neospora caninum | NCLIV_007330 | Similar to uniprot |
Oryza sativa | 4336524 | Os04g0538000 |
Oryza sativa | 4330134 | Os02g0644100 |
Plasmodium berghei | PBANKA_1010500 | Hsp70/Hsp90 organizing protein, putative |
Plasmodium falciparum | PF3D7_1434300 | Hsp70/Hsp90 organizing protein |
Plasmodium knowlesi | PKNH_0420900 | Hsp70/Hsp90 organizing protein, putative |
Plasmodium vivax | PVX_084820 | Hsp70/Hsp90 organizing protein, putative |
Plasmodium yoelii | PY03138 | stress-induced protein sti1-like protein |
Saccharomyces cerevisiae | YOR027W | Hsp90 cochaperone STI1 |
Schistosoma japonicum | Sjp_0217290 | ko:K09553 stress-induced-phosphoprotein 1, putative |
Schistosoma mansoni | Smp_064860 | heat shock protein 70 |
Schmidtea mediterranea | mk4.025349.00 | |
Schmidtea mediterranea | mk4.000342.01 | Stress-induced-phosphoprotein 1 |
Trypanosoma brucei gambiense | Tbg972.5.4130 | stress-induced protein sti1, putative |
Trypanosoma brucei | Tb927.5.2940 | stress-induced protein sti1, putative |
Trypanosoma congolense | TcIL3000_5_2850 | stress-induced protein sti1, putative |
Trypanosoma congolense | TcIL3000_5_3210 | stress-induced protein sti1, putative |
Trypanosoma cruzi | TcCLB.506321.290 | stress-induced protein sti1, putative |
Toxoplasma gondii | TGME49_252220 | tetratricopeptide repeat domain containing protein |
Theileria parva | TP03_0587 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_220990 | chaperone binding protein, putative |
Trichomonas vaginalis | TVAG_069560 | O-linked N-acetylglucosamine transferase, ogt, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.2940 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2940 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2940 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.2940 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_R09E12.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1010500 | Plasmodium berghei | Dispensable | plasmo |
TGME49_252220 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.