Detailed view for PF3D7_1431500

Basic information

TDR Targets ID: 2625
Plasmodium falciparum, mitogen-activated protein kinase 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.8764 | Length (AA): 914 | MW (Da): 107277 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0000165   MAPKKK cascade  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004707   MAP kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 356 2gph (A) 10 354 38.00 0 1 0.68 -1.36
10 467 1koa () 5929 6349 20.00 0 1 0.52 0.54
21 527 3n51 (A) 49 503 22.00 0.00031 1 0.569905 0.62
16 356 3oz6 (A) 4 376 58.00 0 1 0.981921 -0.68
21 522 3nyv (A) 49 498 22.00 0.00056 1 0.603661 0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, sporozoite, Sporozoite, Female Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early schizont, early trophozoite, late trophozoite, Oocyst, Ring, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, early ring, late ring, late schizont. Otto TD PlasmoDB
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129442)

Species Accession Gene Product
Babesia bovis BBOV_IV010480   mitogen activated protein kinase, putative
Caenorhabditis elegans CELE_C05D10.2   Protein C05D10.2, isoform B
Cryptosporidium hominis Chro.20213   mitogen-activated protein kinase 1, serine/threonine protein kinase
Cryptosporidium parvum cgd2_1960   mitogen-activated protein kinase 1, serine/threonine protein kinase, putative
Dictyostelium discoideum DDB_G0283903   ERK subfamily protein kinase
Drosophila melanogaster Dmel_CG32703   Extracellularly regulated kinase 7
Echinococcus granulosus EgrG_000676200   mitogen activated protein kinase 15
Entamoeba histolytica EHI_073650   mitogen-activated protein kinase
Echinococcus multilocularis EmuJ_000676200   mitogen activated protein kinase 15
Giardia lamblia GL50803_22850   Kinase, CMGC MAPK
Homo sapiens ENSG00000181085   mitogen-activated protein kinase 15
Leishmania braziliensis LbrM.35.0840   protein kinase, putative,mitogen-activated protein kinase, putative
Leishmania donovani LdBPK_360780.1   mitogen-activated protein kinase 2
Leishmania infantum LinJ.36.0780   protein kinase, putative,mitogen-activated protein kinase, putative
Leishmania major LmjF.36.0720   protein kinase, putative,mitogen-activated protein kinase, putative
Leishmania mexicana LmxM.36.0720   protein kinase, putative,mitogen-activated protein kinase, putative
Loa Loa (eye worm) LOAG_13928   hypothetical protein
Loa Loa (eye worm) LOAG_11238   hypothetical protein
Mus musculus ENSMUSG00000063704   mitogen-activated protein kinase 15
Neospora caninum NCLIV_032840   Mitogen-activated protein kinase 2, related
Plasmodium berghei PBANKA_1013300   mitogen-activated protein kinase 1
Plasmodium falciparum PF3D7_1431500   mitogen-activated protein kinase 1
Plasmodium knowlesi PKNH_1327200   mitogen-activated protein kinase 1, putative
Plasmodium vivax PVX_084965   mitogen-activated protein kinase 1, putative
Plasmodium yoelii PY02176   mitogen-activated protein kinase
Schistosoma japonicum Sjp_0300800   ko:K08293 mitogen-activated protein kinase [EC2.7.11.24], putative
Schistosoma japonicum Sjp_0001250   Putative serine/threonine-protein kinase C05D10.2, putative
Schistosoma mansoni Smp_133500   serine/threonine protein kinase
Schistosoma mansoni Smp_134260   serine/threonine protein kinase
Schmidtea mediterranea mk4.000459.06   Putative serine/threonine-protein kinase
Trypanosoma brucei gambiense Tbg972.10.6210   protein kinase, putative,mitogen-activated protein kinase, putative
Trypanosoma brucei Tb927.10.5140   Mitogen-activated protein kinase 6
Trypanosoma congolense TcIL3000_10_4300   Mitogen-activated protein kinase 6
Trypanosoma cruzi TcCLB.506007.40   Mitogen-activated protein kinase 6
Trypanosoma cruzi TcCLB.510295.50   Mitogen-activated protein kinase 6
Toxoplasma gondii TGME49_233010   cell-cycle-assocaited protein kinase ERK7, putative
Theileria parva TP01_0678   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_260190   CMGC family protein kinase
Trichomonas vaginalis TVAG_045770   CMGC family protein kinase
Trichomonas vaginalis TVAG_418770   CMGC family protein kinase
Trichomonas vaginalis TVAG_192740   CMGC family protein kinase
Trichomonas vaginalis TVAG_319710   CMGC family protein kinase

Essentiality

PF3D7_1431500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5140 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5140 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5140 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C05D10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C05D10.2 Caenorhabditis elegans larval arrest wormbase
CELE_C05D10.2 Caenorhabditis elegans sterile wormbase
PBANKA_1013300 Plasmodium berghei Dispensable plasmo
TGME49_233010 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase 15 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Zea mays Casein kinase II alpha 332 aa 31.6% 307 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 28.1% 292 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 43.2% 308 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 37.0% 297 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 37.8% 296 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.6% 330 aa Compounds References
Patiria pectinifera Cdc2 300 aa 36.1% 313 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 42.3% 310 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.8% 233 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 43.1% 174 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 37.0% 300 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.4477 0.5
0.0081 1 0.5
0.0056 1 0.5
0.0032 0.5 0.5
0.0093 0.8828 0
0.0063 0.7244 0.7244
0.0022 0.5 0.5
0.0059 1 1
0.0064 0.3377 0
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0033 1 1
0.0007 0.5 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0037 1 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0069 0.3067 1
0.0059 1 1
0.0033 0.5 0.5
0.0063 1 1
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0098 0.3242 0.2614
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0011 1 0.5
0.0092 1 0.5
0.0029 0.5 0.5
0.0008 0.5 0.5
0.0062 0.6935 0
0.0059 1 1
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0066 0.3101 0
0.0026 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 1
0.0039 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1431500 (Plasmodium falciparum), mitogen-activated protein kinase 1
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