pI: 7.4614 |
Length (AA): 537 |
MW (Da): 59768 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
306 | 465 | 3rkg (A) | 165 | 305 | 21.00 | 0 | 0.98 | 0.526352 | -0.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_127894)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G64560 | magnesium transporter MRS2-2 |
Arabidopsis thaliana | AT5G22830 | magnesium transporter 10 |
Candida albicans | CaO19.10128 | Mitochondrial group II intron splicing |
Candida albicans | CaO19.3455 | CorA-like Mg2+ transporter domain-containing orf |
Candida albicans | CaO19.10959 | CorA-like Mg2+ transporter domain-containing orf |
Candida albicans | CaO19.2597 | Mitochondrial group II intron splicing |
Cryptosporidium hominis | Chro.20166 | hypothetical protein |
Cryptosporidium parvum | cgd3_3560 | CorA family mitochondrial membrane protein with 2 transmembrane domains at C-terminus |
Cryptosporidium parvum | cgd2_1520 | hypothetical protein |
Dictyostelium discoideum | DDB_G0275813 | hypothetical protein |
Giardia lamblia | GL50803_14093 | Hypothetical protein |
Homo sapiens | ENSG00000124532 | MRS2 magnesium transporter |
Mus musculus | ENSMUSG00000021339 | MRS2 magnesium homeostasis factor homolog (S. cerevisiae) |
Neospora caninum | NCLIV_001090 | CorA-like Mg2 transporter domain-containing protein, related |
Neospora caninum | NCLIV_033770 | corA-like Mg2 transporter domain-containing protein, putative |
Oryza sativa | 4333741 | Os03g0684400 |
Oryza sativa | 4331553 | Os03g0137700 |
Oryza sativa | 4336308 | Os04g0501100 |
Oryza sativa | 4334067 | Os03g0742400 |
Plasmodium berghei | PBANKA_1017000 | CorA-like Mg2+ transporter protein, putative |
Plasmodium berghei | PBANKA_0927900 | CorA-like Mg2+ transporter protein, putative |
Plasmodium falciparum | PF3D7_1427600 | CorA-like Mg2+ transporter protein, putative |
Plasmodium falciparum | PF3D7_1120300 | CorA-like Mg2+ transporter protein, putative |
Plasmodium knowlesi | PKNH_1331100 | CorA-like Mg2+ transporter protein, putative |
Plasmodium knowlesi | PKNH_0918000 | CorA-like Mg2+ transporter protein, putative |
Plasmodium vivax | PVX_085155 | CorA-like Mg2+ transporter protein, putative |
Plasmodium vivax | PVX_091650 | RNA splicing protein MRS2, mitochondrial precursor, putative |
Plasmodium yoelii | PY00890 | hypothetical protein |
Plasmodium yoelii | PY07158 | Guillardia theta Mrs2p |
Saccharomyces cerevisiae | YPL060W | Mfm1p |
Saccharomyces cerevisiae | YOR334W | Mrs2p |
Toxoplasma gondii | TGME49_305190 | CorA family Mg2+ transporter protein |
Toxoplasma gondii | TGME49_273970 | CorA family Mg2+ transporter protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1017000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_305190 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_273970 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_305190 | Toxoplasma gondii | Probably essential | sidik |
TGME49_273970 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.