pI: 6.7435 |
Length (AA): 932 |
MW (Da): 104329 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
57 | 378 | 1zgk (A) | 335 | 598 | 20.00 | 0 | 1 | 0.19 | -0.15 |
81 | 403 | 2zwa (B) | 380 | 667 | 15.00 | 0 | 1 | 0.371967 | 0.35 |
202 | 240 | 4psw (B) | 183 | 216 | 50.00 | 0.81 | 0.26 | 0.168045 | 2.44 |
758 | 932 | 4uos (A) | 6 | 182 | 11.00 | 0.17 | 0.02 | 0.368068 | -1.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 Oocyst. | Fritz HM |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_129091)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G50310 | kelch repeat-containing protein |
Babesia bovis | BBOV_III006990 | kelch repeat containing protein |
Candida albicans | CaO19.12476 | Kelch-repeat |
Candida albicans | CaO19.5009 | Kelch-repeat |
Cryptosporidium hominis | Chro.70399 | Kelch repeats protein family |
Cryptosporidium parvum | cgd7_3580 | kelch repeats protein |
Drosophila melanogaster | Dmel_CG4069 | CG4069 gene product from transcript CG4069-RA |
Homo sapiens | ENSG00000104731 | kelch domain containing 4 |
Leishmania braziliensis | LbrM.16.0090 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_160090.1 | Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative |
Leishmania infantum | LinJ.16.0090 | hypothetical protein, conserved |
Leishmania major | LmjF.16.0080 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.16.0080 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000040263 | kelch domain containing 4 |
Neospora caninum | NCLIV_030210 | Tip elongation aberrant protein 1, related |
Oryza sativa | 4336203 | Os04g0483600 |
Plasmodium berghei | PBANKA_0506800 | kelch domain-containing protein, putative |
Plasmodium falciparum | PF3D7_1022600 | kelch domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0606900 | kelch domain-containing protein, putative |
Plasmodium vivax | PVX_111590 | kelch domain-containing protein |
Plasmodium yoelii | PY01661 | Arabidopsis thaliana MXI22.1-related |
Saccharomyces cerevisiae | YPL263C | Kel3p |
Trypanosoma brucei gambiense | Tbg972.5.5410 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.5.3900 | Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative |
Trypanosoma congolense | TcIL3000_5_4430 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.504251.30 | Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative |
Trypanosoma cruzi | TcCLB.506947.20 | Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative |
Toxoplasma gondii | TGME49_229290 | kelch repeat-containing protein |
Theileria parva | TP04_0608 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3900 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3900 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3900 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3900 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_229290 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.