Detailed view for TGME49_201750

Basic information

TDR Targets ID: 263095
Toxoplasma gondii, Tctex-1 family protein
Source Database / ID:  ToxoDB 

pI: 4.6882 | Length (AA): 123 | MW (Da): 14216 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03645   Tctex-1 family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 145 1xdx (A) 4 112 20.00 0 0.99 1.05 -0.38
43 145 1ygt (A) 10 109 17.00 0 0.51 0.95 -0.72
11 121 1xdx (A) 6 113 19.00 0 1 1.10924 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile VEG Tachyzoite, ME49 Tachyzoite. Gregory
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 merozoite. Hehl AB
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile ME49 Oocyst, ME49 Bradyzoite. Fritz HM Sibley/Greg
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_129176)

Species Accession Gene Product
Caenorhabditis elegans CELE_D1009.5   Protein DYLT-2
Drosophila melanogaster Dmel_CG5359   CG5359 gene product from transcript CG5359-RC
Echinococcus granulosus EgrG_001159200   Tctex 1
Echinococcus multilocularis EmuJ_001159200   Tctex 1
Giardia lamblia GL50803_15606   Dynein light chain
Giardia lamblia GL50803_17371   Dynein light chain
Homo sapiens ENSG00000213123   Tctex1 domain containing 2
Leishmania braziliensis LbrM.34.2820   hypothetical protein, conserved
Leishmania donovani LdBPK_352960.1   dynein light chain, putative
Leishmania infantum LinJ.35.2960   hypothetical protein, conserved
Leishmania major LmjF.35.2910   hypothetical protein, conserved
Leishmania mexicana LmxM.34.2910   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03015   hypothetical protein
Mus musculus ENSMUSG00000014075   Tctex1 domain containing 2
Neospora caninum NCLIV_023000   hypothetical protein
Plasmodium berghei PBANKA_0933600   dynein light chain Tctex-type, putative
Plasmodium berghei PBANKA_0902000   dynein light chain, putative
Plasmodium falciparum PF3D7_1114000   dynein light chain Tctex-type, putative
Plasmodium falciparum PF3D7_1147100   dynein light chain, putative
Plasmodium knowlesi PKNH_0944900   dynein light chain, putative
Plasmodium knowlesi PKNH_0911600   dynein light chain Tctex-type, putative
Plasmodium vivax PVX_091345   dynein light chain type 2, putative
Plasmodium vivax PVX_092947   dynein light chain, putative
Plasmodium yoelii PY00730   hypothetical protein
Schistosoma japonicum Sjp_0052460   IPR005334,Tctex-1,domain-containing
Schistosoma mansoni Smp_158660   axonemal dynein light chain
Schmidtea mediterranea mk4.002522.02   Dynein light chain 3'
Schmidtea mediterranea mk4.005949.01   Dynein light chain 3'
Schmidtea mediterranea mk4.018871.00   Axonemal dynein light chain, putative
Trypanosoma brucei gambiense Tbg972.9.7870   dynein light chain, putative
Trypanosoma brucei Tb927.9.12820   dynein light chain, putative
Trypanosoma congolense TcIL3000_9_5340   dynein light chain, putative
Trypanosoma cruzi TcCLB.510659.100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507013.30   hypothetical protein, conserved
Toxoplasma gondii TGME49_201750   Tctex-1 family protein
Toxoplasma gondii TGME49_278790   Tctex2-related light chain
Trichomonas vaginalis TVAG_341120   axonemal dynein light chain, putative

Essentiality

TGME49_201750 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.3770 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.3770 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.3770 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.3770 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0902000 Plasmodium berghei Dispensable plasmo
PBANKA_0933600 Plasmodium berghei Dispensable plasmo
TGME49_201750 this record Toxoplasma gondii Probably non-essential sidik
TGME49_278790 Toxoplasma gondii Probably non-essential sidik
TGME49_201750 this record Toxoplasma gondii Essentiality uncertain sidik
TGME49_278790 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TGME49_201750 (Toxoplasma gondii), Tctex-1 family protein
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