pI: 8.2895 |
Length (AA): 1655 |
MW (Da): 183919 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
361 | 436 | 2m3k (A) | 13 | 91 | 36.00 | 0.83 | 0.15 | 0.0789215 | 1.54 |
1547 | 1644 | 4psn (A) | 2 | 97 | 14.00 | 0 | 0.05 | 0.283015 | -1.25 |
1580 | 1623 | 5bs7 (E) | 627 | 671 | 23.00 | 0 | 0.01 | 0.510386 | -3.01 |
1581 | 1645 | 5hmo (A) | 818 | 883 | 35.00 | 0.54 | 0.11 | 0.344275 | -1.72 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 merozoite. | Hehl AB |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128836)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G31260 | protein autophagy 9 |
Brugia malayi | Bm1_19730 | Autophagy protein Apg9 containing protein |
Candida albicans | CaO19.5974 | similar to S. cerevisiae integral membrane protein ATG9 (YDL149W)required for starvation-induced autophagy |
Candida albicans | CaO19.13395 | similar to S. cerevisiae integral membrane protein ATG9 (YDL149W)required for starvation-induced autophagy |
Caenorhabditis elegans | CELE_T22H9.2 | Protein ATG-9, isoform B |
Dictyostelium discoideum | DDB_G0285323 | autophagy protein 9 |
Drosophila melanogaster | Dmel_CG3615 | Autophagy-specific gene 9 |
Echinococcus granulosus | EgrG_000863500 | autophagy protein 9A |
Echinococcus multilocularis | EmuJ_000863500 | autophagy protein 9A |
Homo sapiens | ENSG00000198925 | autophagy related 9A |
Homo sapiens | ENSG00000181652 | autophagy related 9B |
Loa Loa (eye worm) | LOAG_06183 | autophagy protein Apg9 containing protein |
Loa Loa (eye worm) | LOAG_11667 | autophagy protein Apg9 containing protein |
Loa Loa (eye worm) | LOAG_08850 | hypothetical protein |
Mus musculus | ENSMUSG00000033124 | autophagy related 9A |
Mus musculus | ENSMUSG00000038295 | autophagy related 9B |
Neospora caninum | NCLIV_026420 | autophagy protein APG9, putative |
Oryza sativa | 4332250 | Os03g0248000 |
Saccharomyces cerevisiae | YDL149W | Atg9p |
Schistosoma japonicum | Sjp_0042780 | Autophagy-related protein 9A, putative |
Schistosoma japonicum | Sjp_0119350 | Autophagy-related protein 9A, putative |
Schistosoma japonicum | Sjp_0309690 | Autophagy-related protein 9A, putative |
Schistosoma mansoni | Smp_149960 | hypothetical protein |
Schmidtea mediterranea | mk4.009044.00 | |
Toxoplasma gondii | TGME49_260640 | autophagy protein apg9 protein |
Trichomonas vaginalis | TVAG_426560 | autophagy protein, putative |
Trichomonas vaginalis | TVAG_283090 | autophagy protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T22H9.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_260640 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.