pI: 6.0511 |
Length (AA): 776 |
MW (Da): 83987 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
65 | 603 | 5jqs (A) | 111 | 365 | 35.00 | 0 | 1 | -0.256412 | 2.35 |
599 | 701 | 5szh (A) | 564 | 671 | 14.00 | 0 | 0.01 | 0.485532 | -2.27 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128472)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G11860 | hypothetical protein |
Arabidopsis thaliana | AT4G22960 | hypothetical protein |
Babesia bovis | BBOV_II005380 | hypothetical protein |
Brugia malayi | Bm1_39690 | hypothetical protein |
Candida albicans | CaO19.3615 | similar to S. cerevisiae YPL191C |
Candida albicans | CaO19.11098 | similar to S. cerevisiae YPL191C |
Caenorhabditis elegans | CELE_Y55F3AM.9 | Protein Y55F3AM.9 |
Dictyostelium discoideum | DDB_G0281445 | DUF544 family protein |
Dictyostelium discoideum | DDB_G0269770 | DUF544 family protein |
Echinococcus granulosus | EgrG_000900800 | protein FAM63A |
Echinococcus multilocularis | EmuJ_000900800 | protein FAM63A |
Homo sapiens | ENSG00000143409 | family with sequence similarity 63, member A |
Homo sapiens | ENSG00000128923 | family with sequence similarity 63, member B |
Loa Loa (eye worm) | LOAG_08127 | hypothetical protein |
Loa Loa (eye worm) | LOAG_16234 | hypothetical protein |
Mus musculus | ENSMUSG00000042444 | family with sequence similarity 63, member B |
Mus musculus | ENSMUSG00000038712 | family with sequence similarity 63, member A |
Neospora caninum | NCLIV_002350 | hypothetical protein |
Oryza sativa | 4342044 | Os06g0712400 |
Oryza sativa | 4342094 | Os06g0721600 |
Onchocerca volvulus | OVOC5059 |
|
Plasmodium berghei | PBANKA_1417600 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_1319100 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1419900 | conserved protein, unknown function |
Plasmodium vivax | PVX_122770 | conserved protein, unknown function |
Plasmodium yoelii | PY03275 | hypothetical protein |
Saccharomyces cerevisiae | YGL082W | hypothetical protein |
Saccharomyces cerevisiae | YPL191C | hypothetical protein |
Schistosoma japonicum | Sjp_0091350 | IPR007518,Protein of unknown function DUF544,domain-containing |
Schistosoma japonicum | Sjp_0034890 | similar to Uncharacterized protein YPL191C, putative |
Schistosoma mansoni | Smp_042990.2 | hypothetical protein |
Schistosoma mansoni | Smp_042990.1 | hypothetical protein |
Schmidtea mediterranea | mk4.021421.00 | |
Schmidtea mediterranea | mk4.022214.01 | |
Trypanosoma brucei gambiense | Tbg972.6.4190 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.4380 | Protein of unknown function (DUF544), putative |
Trypanosoma congolense | TcIL3000_6_3800 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509167.200 | Protein of unknown function (DUF544), putative |
Trypanosoma cruzi | TcCLB.509065.170 | Protein of unknown function (DUF544), putative |
Toxoplasma gondii | TGME49_295400 | hypothetical protein |
Theileria parva | TP02_0489 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4380 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4380 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4380 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_295400 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.