pI: 5.4062 |
Length (AA): 378 |
MW (Da): 41458 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
51 | 96 | 2mar (A) | 48 | 93 | 33.00 | 0.73 | 0.04 | 0.572493 | -1.22 |
183 | 367 | 3tmp (A) | 178 | 340 | 27.00 | 0 | 1 | 0.643318 | -0.17 |
183 | 366 | 3tmp (A) | 178 | 339 | 29.00 | 0.0000066 | 1 | 0.624573 | 0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_128771)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G62940 | cysteine proteinases family protein |
Babesia bovis | BBOV_III011220 | hypothetical protein |
Brugia malayi | Bm1_02270 | OTU-like cysteine protease family protein |
Candida albicans | CaO19.1959 | similar to S. cerevisiae YHL013C |
Candida albicans | CaO19.9514 | similar to S. cerevisiae YHL013C |
Caenorhabditis elegans | CELE_F21D5.2 | Protein OTUB-3, isoform C |
Cryptosporidium hominis | Chro.40502 | hypothetical protein |
Cryptosporidium parvum | cgd4_4430 | OTU like cysteine protease |
Dictyostelium discoideum | DDB_G0279375 | OTU domain containin protein |
Drosophila melanogaster | Dmel_CG7857 | CG7857 gene product from transcript CG7857-RA |
Echinococcus granulosus | EgrG_000728500 | OTU domain containing protein 6B |
Echinococcus multilocularis | EmuJ_000728500 | OTU domain containing protein 6B |
Homo sapiens | ENSG00000155100 | OTU domain containing 6B |
Loa Loa (eye worm) | LOAG_04191 | hypothetical protein |
Mus musculus | ENSMUSG00000040550 | OTU domain containing 6B |
Neospora caninum | NCLIV_018240 | Similar to uniprot |
Oryza sativa | 4337022 | Os04g0619500 |
Plasmodium berghei | PBANKA_0907300 | OTU domain-containing protein, putative |
Plasmodium falciparum | PF3D7_1141700 | OTU domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0939500 | OTU domain-containing protein, putative |
Plasmodium vivax | PVX_092690 | hypothetical protein, conserved |
Plasmodium yoelii | PY03414 | hypothetical protein |
Saccharomyces cerevisiae | YHL013C | Otu2p |
Schistosoma japonicum | Sjp_0012110 | OTU domain-containing protein 2, putative |
Schistosoma mansoni | Smp_030280.2 | C64 protease (C64 family) |
Schmidtea mediterranea | mk4.000046.08 | |
Toxoplasma gondii | TGME49_243510 | OTU family cysteine protease |
Theileria parva | TP02_0742 | hypothetical protein |
Trichomonas vaginalis | TVAG_101350 | OTU domain-containing protein 6B, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_243510 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.