Detailed view for PF3D7_1432300

Basic information

TDR Targets ID: 2635
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.8533 | Length (AA): 1639 | MW (Da): 196970 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03810   Importin-beta N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008536   Ran GTPase binding  
GO:0005737   cytoplasm  
GO:0005643   nuclear pore  
GO:0005634   nucleus  
GO:0008565   protein transporter activity  
GO:0005488   binding  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 22 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 995 1wa5 (C) 1 954 18.00 0 1 0.77 -0.52
10 282 1ibr (B) 2 269 12.00 0 0.76 0.27 -1.51
521 1583 1epw (A) 5 1159 19.00 0 0.98 0.76 -0.04
1 201 3a6p (A) 3 209 13.00 0.00028 0.96 0.319836 -0.65
5 144 3w3z (A) 6 154 18.00 0.027 0.71 0.360618 -0.98
27 235 1z3h (B) 21 244 25.00 0.52 0.99 0.292917 0.02
311 588 2yk0 (A) 387 707 28.00 0.32 0.28 -0.0399844 1.76
713 1624 3v0a (B) 185 1144 23.00 0.00081 0.76 0.474637 1.74
823 1585 3ffz (A) 321 1165 25.00 0.22 0.86 0.345928 1.84
1235 1333 3ult (A) 9 107 20.00 0.76 0.01 0.355603 -1.08
1287 1575 2fds (A) 6 317 28.00 0.17 0.26 0.149727 0.51
1292 1603 2fds (A) 14 324 20.00 0.015 0.7 0.27216 0.01
1299 1548 2fds (A) 3 281 22.00 0.49 0.48 0.210732 -0.04
1360 1542 4u5a (C) 47 239 21.00 0.41 0.22 0.269453 -0.43
3 932 1z3h (A) 3 957 15.00 0.00000009 1 0.605712 0.41
5 144 3w3w (A) 6 154 18.00 0.38 0.43 0.361722 -0.84
129 946 3v0a (B) 221 1185 26.00 0.00039 0.99 0.372295 1.84
785 1072 4u0r (A) 161 490 23.00 0.33 0.36 0.154132 0.67
828 1615 3ffz (A) 321 1080 23.00 0.14 0.89 0.515968 1.22
1240 1329 3ult (A) 9 106 29.00 0.62 0.02 0.327179 -0.71
1292 1573 2fds (A) 6 317 28.00 0.64 0.18 0.180866 0.27
1358 1540 4u5a (C) 47 239 22.00 0.24 0.43 0.29439 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early schizont, late schizont. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early trophozoite, late ring, late trophozoite, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst, Ring, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_161776)

Species Accession Gene Product
Plasmodium berghei PBANKA_1012600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1432300   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0418800   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_084930   hypothetical protein, conserved
Plasmodium yoelii PY04054   hypothetical protein
Trichomonas vaginalis TVAG_366650   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1432300 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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