Detailed view for TGME49_286800

Basic information

TDR Targets ID: 263551
Toxoplasma gondii, hypothetical protein
Source Database / ID:  ToxoDB 

pI: 4.9383 | Length (AA): 844 | MW (Da): 91263 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13898   Domain of unknown function (DUF4205)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
698 760 1s6j (A) 14 83 37.00 1 0.38 0.257045 1.09
699 844 3kf9 (A) 22 157 13.00 0.0021 0.73 0.103986 1.15
702 763 2f2o (B) 81 146 37.00 0.9 0.98 0.35086 0.44
773 844 2ami (A) 5 67 10.00 0.11 0.01 -0.0936919 1.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile ME49 merozoite. Hehl AB
Show/Hide expression data references
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_130604)

Species Accession Gene Product
Arabidopsis thaliana AT1G43690   ubiquitin interaction motif-containing protein
Babesia bovis BBOV_III009050   hypothetical protein
Cryptosporidium hominis Chro.30416   hypothetical protein
Cryptosporidium parvum cgd3_3680   UIM domain and EF hand containing protein that also has a conserved domain between
Drosophila melanogaster Dmel_CG7332   CG7332 gene product from transcript CG7332-RB
Echinococcus granulosus EgrG_001011700   protein FAM188A
Echinococcus multilocularis EmuJ_001011700   protein FAM188A
Homo sapiens ENSG00000148481   family with sequence similarity 188, member A
Mus musculus ENSMUSG00000026767   family with sequence similarity 188, member A
Neospora caninum NCLIV_013860   F2J6.5 protein, related
Oryza sativa 4335833   Os04g0421800
Plasmodium berghei PBANKA_1129400   conserved protein, unknown function
Plasmodium falciparum PF3D7_0630600   conserved protein, unknown function
Plasmodium knowlesi PKNH_1118900   conserved protein, unknown function
Plasmodium vivax PVX_114630   hypothetical protein, conserved
Plasmodium yoelii PY04518   Mus musculus RIKEN cDNA 2310047O13 gene
Schistosoma japonicum Sjp_0053940   Protein CARP, putative
Schistosoma mansoni Smp_181460   hypothetical protein
Toxoplasma gondii TGME49_286800   hypothetical protein
Theileria parva TP04_0809   hypothetical protein, conserved
Trichomonas vaginalis TVAG_476550   conserved hypothetical protein
Trichomonas vaginalis TVAG_106700   conserved hypothetical protein

Essentiality

TGME49_286800 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
TGME49_286800 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_286800 (Toxoplasma gondii), hypothetical protein
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