Detailed view for LmjF.36.0050

Basic information

TDR Targets ID: 26364
Leishmania major, PUF1, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6663 | Length (AA): 553 | MW (Da): 61267 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00806   Pumilio-family RNA binding repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0003723   RNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 425 1ib2 (A) 829 1149 24.00 0 1 0.73 -0.63
103 412 1ib2 (A) 841 1136 27.00 0 1 0.83 -0.98
49 443 3k49 (A) 522 873 24.00 0 1 0.808586 0
50 441 3bwt (A) 554 885 32.00 0 1 0.953261 -0.31
78 442 1m8z (A) 844 1166 27.00 0 1 0.905336 -0.51
83 442 3v71 (A) 102 451 17.00 0 1 0.693295 -0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_149040)

Species Accession Gene Product
Leishmania braziliensis LbrM.35.0090   PUF1, putative
Leishmania donovani LdBPK_360050.1   PUF1, putative
Leishmania infantum LinJ.36.0050   PUF1, putative
Leishmania major LmjF.36.0050   PUF1, putative
Leishmania mexicana LmxM.36.0050   PUF1, putative
Trypanosoma brucei gambiense Tbg972.10.5460   pumillo RNA binding protein PUF1
Trypanosoma brucei Tb927.10.4430   pumillo RNA binding protein PUF1
Trypanosoma brucei Tb10.v4.0033   pumillo RNA binding protein PUF1
Trypanosoma brucei Tb11.v5.0767   pumillo RNA binding protein PUF1, putative
Trypanosoma congolense TcIL3000_10_3630   pumillo RNA binding protein PUF1, putative
Trypanosoma cruzi TcCLB.397937.10   pumilio/PUF RNA binding protein 1, putative
Trypanosoma cruzi TcCLB.508625.160   pumilio/PUF RNA binding protein 1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.0050 (Leishmania major), PUF1, putative
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