pI: 8.9276 |
Length (AA): 2141 |
MW (Da): 232351 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1115 | 2073 | 4rnp (A) | 7 | 883 | 24.00 | 0 | 1 | -0.14 | 1.54 |
477 | 540 | 1oqy (A) | 84 | 143 | 40.00 | 0.29 | 0.01 | 0.322193 | 0.38 |
1195 | 1380 | 4uos (A) | 1 | 185 | 11.00 | 0.0021 | 0.04 | 0.247975 | -1.08 |
1203 | 1345 | 4cpc (A) | 81 | 223 | 9.00 | 0.38 | 0 | 0.164891 | -0.49 |
1226 | 2140 | 4boc (A) | 397 | 1229 | 29.00 | 0 | 1 | 0.50647 | 0.4 |
1368 | 1442 | 2mqa (A) | 22 | 96 | 13.00 | 0 | 0.01 | 0.21763 | -0.86 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_127975)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G15700 | DNA-directed RNA polymerase 2 |
Arabidopsis thaliana | AT1G68990 | DNA-directed RNA polymerase 1, mitochondrial |
Arabidopsis thaliana | AT2G24120 | DNA-directed RNA polymerase 3 |
Babesia bovis | BBOV_III002990 | DNA-dependent RNA polymerase, putative |
Brugia malayi | Bm1_24475 | DNA-dependent RNA polymerase family protein |
Candida albicans | CaO19.13462 | Mitochondrial RNA polymerase |
Candida albicans | CaO19.6041 | Mitochondrial RNA polymerase |
Caenorhabditis elegans | CELE_Y105E8A.23 | Protein Y105E8A.23, isoform A |
Dictyostelium discoideum | DDB_G0267416 | DNA-dependent RNA polymerase |
Drosophila melanogaster | Dmel_CG4644 | mitochondrial RNA polymerase |
Echinococcus granulosus | EgrG_000150100 | t3:t7 bacteriophage mitochodrial |
Echinococcus multilocularis | EmuJ_000150100 | t3:t7 bacteriophage mitochodrial |
Homo sapiens | ENSG00000099821 | polymerase (RNA) mitochondrial (DNA directed) |
Leishmania braziliensis | LbrM.24.1170 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania donovani | LdBPK_241180.1 | DNA-directed RNA polymerase, mitochondrial |
Leishmania infantum | LinJ.24.1180 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania major | LmjF.24.1150 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania mexicana | LmxM.24.1150 | mitochondrial DNA-directed RNA polymerase, putative |
Loa Loa (eye worm) | LOAG_10422 | DNA-dependent RNA polymerase |
Mus musculus | ENSMUSG00000020329 | polymerase (RNA) mitochondrial (DNA directed) |
Neospora caninum | NCLIV_063080 | DNA-directed RNA polymerase (EC 2.7.7.6), related |
Oryza sativa | 4346491 | Os09g0246200 |
Oryza sativa | 4341695 | Os06g0652000 |
Plasmodium berghei | PBANKA_0923000 | DNA-directed RNA polymerase, putative |
Plasmodium falciparum | PF3D7_1125300 | DNA-directed RNA polymerase |
Plasmodium knowlesi | PKNH_0923200 | DNA-directed RNA polymerase, putative |
Plasmodium vivax | PVX_091885 | DNA-dependent RNA polymerase, putative |
Plasmodium yoelii | PY06560 | DNA-dependent RNA polymerase-related |
Plasmodium yoelii | PY06559 | DNA-dependent RNA polymerase-related |
Saccharomyces cerevisiae | YFL036W | Rpo41p |
Schistosoma japonicum | Sjp_0010530 | ko:K00960 DNA-directed RNA polymerase [EC2.7.7.6], putative |
Schistosoma mansoni | Smp_148720 | t3/t7 bacteriophage-related mitochodrial DNA-directed rna polymerase |
Schmidtea mediterranea | mk4.000959.08 | |
Schmidtea mediterranea | mk4.000959.09 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.6520 | mitochondrial DNA-directed RNA polymerase, putative |
Trypanosoma brucei | Tb927.11.5780 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma congolense | TcIL3000.11.6160 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma congolense | TcIL3000_0_56560 | mitochondrial DNA-directed RNA polymerase |
Trypanosoma cruzi | TcCLB.508641.260 | DNA-directed RNA polymerase, mitochondrial |
Toxoplasma gondii | TGME49_246060 | DNA-dependent RNA polymerase |
Theileria parva | TP01_0975 | DNA-directed RNA polymerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3530 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3530 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3530 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.3530 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y105E8A.23 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_246060 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3