pI: 5.4727 |
Length (AA): 1169 |
MW (Da): 126247 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
276 | 322 | 1m1h (A) | 135 | 185 | 15.00 | 0.000019 | 0.05 | 0.19 | -0.88 |
56 | 141 | 5hmo (A) | 805 | 890 | 22.00 | 0.32 | 0 | 0.452567 | -1.68 |
231 | 323 | 3h7h (B) | 176 | 268 | 41.00 | 0.0000000004 | 1 | 0.661555 | -1.01 |
491 | 599 | 4ytl (A) | 534 | 631 | 21.00 | 0 | 0.67 | 0.218542 | 0.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_127919)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G08350 | global transcription factor group A2 |
Arabidopsis thaliana | AT2G34210 | transcription elongation factor Spt5 |
Babesia bovis | BBOV_III000200 | KOW motif family protein |
Brugia malayi | Bm1_19900 | Micro-fibrillar-associated protein 1 C-terminus containing protein |
Candida albicans | CaO19.9028 | similar to S. cerevisiae SPT5 (YML010W) RNA Pol II transcription elongation factor |
Candida albicans | CaO19.1453 | similar to S. cerevisiae SPT5 (YML010W) RNA Pol II transcription elongation factor |
Caenorhabditis elegans | CELE_K08E4.1 | Protein SPT-5 |
Cryptosporidium hominis | Chro.60534 | spt5-like transcription initiation protein |
Cryptosporidium parvum | cgd6_4650 | 5kows transcription initiation protein SPT5 |
Dictyostelium discoideum | DDB_G0287661 | transcription initiation factor Spt5 |
Drosophila melanogaster | Dmel_CG7626 | CG7626 gene product from transcript CG7626-RA |
Echinococcus granulosus | EgrG_000788800 | suppressor of Ty 5 |
Entamoeba histolytica | EHI_187280 | transcription initiation factor SPT5, putative |
Echinococcus multilocularis | EmuJ_000788800 | suppressor of Ty 5 |
Echinococcus multilocularis | EmuJ_000011100 | transcription elongation factor spt5 |
Homo sapiens | ENSG00000196235 | suppressor of Ty 5 homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.27.2480 | transcription elongation regulator-like protein |
Leishmania donovani | LdBPK_272220.1 | transcription elongation regulator-like protein |
Leishmania infantum | LinJ.27.2220 | transcription elongation regulator-like protein |
Leishmania major | LmjF.27.2300 | transcription elongation regulator-like protein |
Leishmania mexicana | LmxM.27.2300 | transcription elongation regulator-like protein |
Loa Loa (eye worm) | LOAG_11859 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00211 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00212 | hypothetical protein |
Mus musculus | ENSMUSG00000003435 | suppressor of Ty 5 |
Neospora caninum | NCLIV_032830 | hypothetical protein |
Oryza sativa | 9267296 | Os02g0772000 |
Plasmodium berghei | PBANKA_0109200 | transcription elongation factor SPT5, putative |
Plasmodium falciparum | PF3D7_0610900 | transcription elongation factor SPT5, putative |
Plasmodium knowlesi | PKNH_1139500 | transcription elongation factor SPT5, putative |
Plasmodium vivax | PVX_113680 | transcription elongation factor SPT5, putative |
Plasmodium yoelii | PY03112 | similar to suppressor of Ty 5 homolog |
Saccharomyces cerevisiae | YML010W | transcription elongation factor SPT5 |
Schistosoma japonicum | Sjp_0020680 | expressed protein |
Schistosoma japonicum | Sjp_0079130 | Transcription elongation factor SPT5, putative |
Schistosoma mansoni | Smp_151070 | suppressor of ty |
Schmidtea mediterranea | mk4.000247.06 | Transcription elongation factor SPT5 |
Schmidtea mediterranea | mk4.000247.05 | |
Schmidtea mediterranea | mk4.000339.07 | Transcription elongation factor SPT5 |
Trypanosoma brucei gambiense | Tbg.972.2.3050 | transcription initiation protein, putative |
Trypanosoma brucei | Tb927.2.5030 | transcription initiation protein, putative |
Trypanosoma congolense | TcIL3000_2_1190 | transcription initiation protein, putative |
Trypanosoma cruzi | TcCLB.511625.10 | transcription initiation protein, putative |
Trypanosoma cruzi | TcCLB.504741.60 | transcription initiation protein, putative |
Toxoplasma gondii | TGME49_233000 | KOW motif domain-containing protein |
Theileria parva | TP03_0828 | transcription factor, putative |
Trichomonas vaginalis | TVAG_420180 | suppressor of ty, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.5030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5030 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.5030 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K08E4.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_K08E4.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K08E4.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08E4.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K08E4.1 | Caenorhabditis elegans | sterile | wormbase |
YML010W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0109200 | Plasmodium berghei | Slow | plasmo |
TGME49_233000 this record | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.