Detailed view for PF3D7_1432500

Basic information

TDR Targets ID: 2638
Plasmodium falciparum, RNA methyltransferase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.6065 | Length (AA): 444 | MW (Da): 51847 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02598   Putative RNA methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0005575   cellular_component  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 176 4uos (A) 1 183 17.00 0.031 0.04 0.613244 -1.18
80 443 4rg1 (A) 69 368 38.00 0 1 0.83992 0.62
200 439 4rg1 (A) 139 364 42.00 0 1 0.795041 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, gametocyte, sporozoite, early ring, late ring, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, early schizont, early trophozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128701)

Species Accession Gene Product
Arabidopsis thaliana AT5G19300   hypothetical protein
Babesia bovis BBOV_IV005600   conserved hypothetical protein
Brugia malayi Bm1_41300   Uncharacterized ACR, COG2106 family protein
Candida albicans CaO19.4563   similar to S. cerevisiae YMR310C
Candida albicans CaO19.12032   similar to S. cerevisiae YMR310C
Caenorhabditis elegans CELE_B0361.6   Protein B0361.6
Cryptosporidium hominis Chro.70506   DKFZp566D143.1
Cryptosporidium parvum cgd7_4590   Mth1. SpoU superfamily - SPOUT methylase
Dictyostelium discoideum DDB_G0286505   DUF171 family protein
Drosophila melanogaster Dmel_CG12128   CG12128 gene product from transcript CG12128-RB
Homo sapiens ENSG00000198917   chromosome 9 open reading frame 114
Loa Loa (eye worm) LOAG_09988   hypothetical protein
Loa Loa (eye worm) LOAG_06822   hypothetical protein
Mus musculus ENSMUSG00000039660   DNA segment, Chr 2, Wayne State University 81, expressed
Neospora caninum NCLIV_014470   hypothetical protein, conserved
Oryza sativa 4335294   Os04g0244500
Onchocerca volvulus OVOC8717  
Onchocerca volvulus OVOC8712  
Plasmodium berghei PBANKA_1012400   RNA methyltransferase, putative
Plasmodium falciparum PF3D7_1432500   RNA methyltransferase, putative
Plasmodium knowlesi PKNH_0419100   RNA methyltransferase, putative
Plasmodium vivax PVX_084920   RNA methyltransferase, putative
Plasmodium yoelii PY04902   Uncharacterized ACR, COG2106, putative
Saccharomyces cerevisiae YMR310C   hypothetical protein
Saccharomyces cerevisiae YGR283C   hypothetical protein
Schmidtea mediterranea mk4.015284.01  
Schmidtea mediterranea mk4.002309.05  
Schmidtea mediterranea mk4.002309.06  
Schmidtea mediterranea mk4.015284.00  
Toxoplasma gondii TGME49_285950   hypothetical protein
Theileria parva TP01_0368   hypothetical protein, conserved

Essentiality

PF3D7_1432500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0361.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0361.6 Caenorhabditis elegans larval arrest wormbase
CELE_B0361.6 Caenorhabditis elegans slow growth wormbase
PBANKA_1012400 Plasmodium berghei Slow plasmo
TGME49_285950 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1432500 (Plasmodium falciparum), RNA methyltransferase, putative
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