Detailed view for LmjF.34.2500

Basic information

TDR Targets ID: 26434
Leishmania major, protein phosphatase 2C-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.1172 | Length (AA): 391 | MW (Da): 41676 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00481   Protein phosphatase 2C

Gene Ontology

Mouse over links to read term descriptions.
GO:0043169   cation binding  
GO:0004722   protein serine/threonine phosphatase activity  
GO:0003824   catalytic activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
97 385 1a6q () 3 298 26.00 0 1 1.08 -0.7
2 133 4k6j (A) 740 878 8.00 0 0.01 0.451796 -0.52
99 385 4rag (A) 5 298 23.00 0.0000000058 1 0.965515 -0.05
106 380 3rt0 (B) 180 503 31.00 0 1 0.897525 -0.73
114 377 2p8e (A) 20 294 32.00 0 1 1.07639 -0.71
115 378 1txo (A) 7 238 22.00 0 1 0.785392 0.01
119 380 3nmv (B) 114 413 38.00 0 1 0.992677 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_132000)

Species Accession Gene Product
Arabidopsis thaliana AT1G43900   putative protein phosphatase 2C 11
Brugia malayi Bm1_05515   Protein phosphatase 2C containing protein
Caenorhabditis elegans CELE_T19C3.8   Protein FEM-2
Drosophila melanogaster Dmel_CG10376   CG10376 gene product from transcript CG10376-RA
Entamoeba histolytica EHI_200680   protein phosphatase domain-containing protein
Homo sapiens ENSG00000175175   protein phosphatase, Mg2+/Mn2+ dependent, 1E
Leishmania braziliensis LbrM.20.2040   protein phosphatase 2C-like protein
Leishmania donovani LdBPK_342310.1   protein phosphatase 2C-like protein
Leishmania infantum LinJ.34.2310   protein phosphatase 2C-like protein
Leishmania major LmjF.34.2500   protein phosphatase 2C-like protein
Leishmania mexicana LmxM.33.2500   protein phosphatase 2C-like protein
Mus musculus ENSMUSG00000046442   protein phosphatase 1E (PP2C domain containing)
Oryza sativa 4341949   Os06g0698300
Oryza sativa 4328306   Os02g0149800

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Calcineurin (3.1.3.16 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

15 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.34.2500 (Leishmania major), protein phosphatase 2C-like protein
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