pI: 6.3953 |
Length (AA): 441 |
MW (Da): 48331 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 441 | 1wyu (B) | 6 | 447 | 14.00 | 0 | 1 | 0.94 | 0.31 |
32 | 435 | 2oat (A) | 38 | 439 | 51.00 | 0 | 1 | 1.56 | -1.28 |
18 | 439 | 4nog (A) | 18 | 439 | 99.99 | 0 | 1 | 2.16632 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | VEG Tachyzoite, ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 Bradyzoite. | Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_126982)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G80600 | acetylornithine aminotransferase |
Arabidopsis thaliana | AT5G46180 | ornithine-delta-aminotransferase |
Candida albicans | CaO19.11254 | Acetylornithine aminotransferase |
Candida albicans | CaO19.5641 | Ornithine aminotransferase |
Candida albicans | CaO19.13086 | Ornithine aminotransferase |
Candida albicans | CaO19.3770 | corresponds to N-terminus of S. cerevisiae ARG8 and allelic CaP19.11254 |
Candida albicans | CaO19.3771 | Acetylornithine aminotransferase |
Caenorhabditis elegans | CELE_C16A3.10 | Protein C16A3.10, isoform C |
Dictyostelium discoideum | DDB_G0287913 | ornithine 5-aminotransferase |
Dictyostelium discoideum | DDB_G0269526 | acetylornithine 5-aminotransferase |
Drosophila melanogaster | Dmel_CG8782 | Ornithine aminotransferase precursor |
Escherichia coli | b1748 | succinylornithine transaminase, PLP-dependent |
Escherichia coli | b3359 | bifunctional acetylornithine aminotransferase/succinyldiaminopimelate aminotransferase |
Echinococcus granulosus | EgrG_001032250 | Aminotransferase class III |
Echinococcus granulosus | EgrG_001032200 | ornithine aminotransferase |
Echinococcus multilocularis | EmuJ_001032250 | Aminotransferase class III |
Echinococcus multilocularis | EmuJ_001032200 | ornithine aminotransferase |
Echinococcus multilocularis | EmuJ_000015700 | ornithine aminotransferase |
Homo sapiens | ENSG00000065154 | ornithine aminotransferase |
Mycobacterium leprae | ML1409 | Probable Acetylornithine aminotransferase ArgD |
Mus musculus | ENSMUSG00000030934 | ornithine aminotransferase |
Mycobacterium tuberculosis | Rv1655 | Probable acetylornithine aminotransferase ArgD |
Mycobacterium ulcerans | MUL_1243 | ornithine aminotransferase RocD1 and RocD2 |
Mycobacterium ulcerans | MUL_1647 | acetylornithine aminotransferase |
Neospora caninum | NCLIV_037280 | ornithine aminotransferase, putative |
Oryza sativa | 4333554 | Os03g0643300 |
Oryza sativa | 4337697 | Os05g0129100 |
Plasmodium berghei | PBANKA_0107400 | ornithine aminotransferase, putative |
Plasmodium falciparum | PF3D7_0608800 | ornithine aminotransferase |
Plasmodium knowlesi | PKNH_1141400 | ornithine aminotransferase, putative |
Plasmodium vivax | PVX_113600 | ornithine aminotransferase, putative |
Plasmodium yoelii | PY00104 | ornithine aminotransferase |
Saccharomyces cerevisiae | YOL140W | acetylornithine transaminase |
Saccharomyces cerevisiae | YLR438W | ornithine-oxo-acid transaminase |
Schistosoma japonicum | Sjp_0302240 | ko:K00819 ornithine--oxo-acid transaminase [EC2.6.1.13], putative |
Schistosoma mansoni | Smp_000660 | ornithine--oxo-acid transaminase |
Schmidtea mediterranea | mk4.045935.00 | |
Schmidtea mediterranea | mk4.029046.00 | |
Schmidtea mediterranea | mk4.024830.00 | |
Schmidtea mediterranea | mk4.009106.02 | |
Schmidtea mediterranea | mk4.065769.01 | |
Schmidtea mediterranea | mk4.058932.01 | |
Schmidtea mediterranea | mk4.024830.01 | |
Schmidtea mediterranea | mk4.007450.00 | |
Toxoplasma gondii | TGME49_269110 | ornithine aminotransferase, mitochondrial precursor, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0129 | acetylornithine transaminase protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1684 | Mycobacterium tuberculosis | essential | nmpdr |
b1748 | Escherichia coli | non-essential | goodall |
b3359 | Escherichia coli | non-essential | goodall |
PBANKA_0107400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_269110 this record | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ornithine aminotransferase | Compounds | References |