Detailed view for LmjF.35.3290

Basic information

TDR Targets ID: 26472
Leishmania major, 60S ribosomal subunit protein L31, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.8646 | Length (AA): 188 | MW (Da): 21260 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01198   Ribosomal protein L31e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
85 160 1vq8 (X) 7 83 26.00 0 1 0.73 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126907)

Species Accession Gene Product
Arabidopsis thaliana AT2G19740   60S ribosomal protein L31-1
Arabidopsis thaliana AT4G26230   60S ribosomal protein L31-2
Babesia bovis BBOV_IV008530   ribosomal protein L31, putative
Brugia malayi Bm1_49585   60S ribosomal protein L31
Caenorhabditis elegans CELE_W09C5.6   Protein RPL-31, isoform B
Cryptosporidium parvum cgd4_2400   60S ribosomal protein L31
Dictyostelium discoideum DDB_G0279061   S60 ribosomal protein L31
Drosophila melanogaster Dmel_CG1821   Ribosomal protein L31
Entamoeba histolytica EHI_068200   60S ribosomal protein L31, putative
Entamoeba histolytica EHI_058080   60S ribosomal protein L31, putative
Entamoeba histolytica EHI_140370   60S ribosomal protein L31, putative
Echinococcus multilocularis EmuJ_000850700   ribosomal protein L31
Giardia lamblia GL50803_16368   Ribosomal protein L31B
Homo sapiens ENSG00000071082   ribosomal protein L31
Leishmania braziliensis LbrM.34.3200   60S ribosomal subunit protein L31, putative
Leishmania braziliensis LbrM.34.3190   60S ribosomal subunit protein L31, putative
Leishmania donovani LdBPK_353330.1   60S ribosomal subunit protein L31, putative
Leishmania infantum LinJ.35.3330   60S ribosomal subunit protein L31, putative
Leishmania infantum LinJ.35.3340   60S ribosomal subunit protein L31, putative
Leishmania major LmjF.35.3280   60S ribosomal subunit protein L31, putative
Leishmania major LmjF.35.3290   60S ribosomal subunit protein L31, putative
Leishmania mexicana LmxM.34.3290   60S ribosomal subunit protein L31, putative
Leishmania mexicana LmxM.34.3280   60S ribosomal subunit protein L31, putative
Loa Loa (eye worm) LOAG_06733   hypothetical protein
Mus musculus ENSMUSG00000073702   ribosomal protein L31
Mus musculus 102641512   60S ribosomal protein L31-like
Neospora caninum NCLIV_048030   hypothetical protein
Oryza sativa 4330533   Os02g0717800
Oryza sativa 4340887   Os06g0319700
Plasmodium berghei PBANKA_1103400   60S ribosomal protein L31, putative
Plasmodium falciparum PF3D7_0503800   60S ribosomal protein L31
Plasmodium knowlesi PKNH_1029800   60S ribosomal protein L31, putative
Plasmodium vivax PVX_097760   60S ribosomal protein L31, putative
Plasmodium yoelii PY00344   Ribosomal protein L31e, putative
Saccharomyces cerevisiae YDL075W   ribosomal 60S subunit protein L31A
Saccharomyces cerevisiae YLR406C   ribosomal 60S subunit protein L31B
Schistosoma japonicum Sjp_0091020   ko:K02910 large subunit ribosomal protein L31e, putative
Schistosoma mansoni Smp_050280   60S ribosomal protein L31
Schmidtea mediterranea mk4.001196.03   60S ribosomal protein L31
Trypanosoma brucei gambiense Tbg972.9.7440   60S ribosomal subunit protein L31, putative
Trypanosoma brucei gambiense Tbg972.9.7430   60S ribosomal subunit protein L31, putative
Trypanosoma brucei Tb927.9.12200   60S ribosomal subunit protein L31, putative
Trypanosoma congolense TcIL3000_0_19940   60S ribosomal subunit protein L31, putative
Trypanosoma congolense TcIL3000_9_5060   60S ribosomal subunit protein L31, putative
Trypanosoma cruzi TcCLB.510663.30   60S ribosomal subunit protein L31, putative
Trypanosoma cruzi TcCLB.510663.19   60S ribosomal subunit protein L31, putative
Trypanosoma cruzi TcCLB.510737.70   60S ribosomal subunit protein L31, putative
Trypanosoma cruzi TcCLB.510737.79   60S ribosomal subunit protein L31, putative
Toxoplasma gondii TGME49_266070   ribosomal protein RPL31
Theileria parva TP01_0924   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_262240   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_306060   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_211390   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_056490   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_298270   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_076410   60S ribosomal protein L31, putative
Trichomonas vaginalis TVAG_068780   60S ribosomal protein L31, putative

Essentiality

LmjF.35.3290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.3270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.3270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.3270 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.3270 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W09C5.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_W09C5.6 Caenorhabditis elegans larval arrest wormbase
CELE_W09C5.6 Caenorhabditis elegans larval lethal wormbase
CELE_W09C5.6 Caenorhabditis elegans slow growth wormbase
CELE_W09C5.6 Caenorhabditis elegans sterile wormbase
PBANKA_1103400 Plasmodium berghei Essential plasmo
TGME49_266070 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.3290 (Leishmania major), 60S ribosomal subunit protein L31, putative
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