Detailed view for PF3D7_1433600

Basic information

TDR Targets ID: 2648
Plasmodium falciparum, signal peptidase complex subunit SPC1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.3032 | Length (AA): 101 | MW (Da): 11573 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06645   Microsomal signal peptidase 12 kDa subunit (SPC12)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005787   signal peptidase complex  
GO:0008233   peptidase activity  
GO:0006465   signal peptide processing  

Metabolic Pathways

Protein export (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 74 1y5l (C) 38 103 35.00 0.43 0.05 0.643355 1.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early schizont, early trophozoite, late ring, late schizont, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, Oocyst, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite, Female Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_129239)

Species Accession Gene Product
Arabidopsis thaliana AT2G22425   putative signal peptidase complex subunit 1
Arabidopsis thaliana AT4G40042   signal peptidase subunit-12
Brugia malayi Bm1_18865   microsomal signal peptidase 12 kDa subunit
Caenorhabditis elegans CELE_C34B2.10   Protein C34B2.10
Dictyostelium discoideum DDB_G0278371   microsomal signal peptidase subunit
Drosophila melanogaster Dmel_CG11500   Spase 12-subunit
Echinococcus granulosus EgrG_000819800   signal peptidase complex subunit 1
Entamoeba histolytica EHI_200720   signal peptidase complex subunit, putative
Entamoeba histolytica EHI_193470   signal peptidase complex subunit, putative
Echinococcus multilocularis EmuJ_000819800   signal peptidase complex subunit 1
Giardia lamblia GL50803_3154   Hypothetical protein
Homo sapiens ENSG00000114902   signal peptidase complex subunit 1 homolog (S. cerevisiae)
Mus musculus ENSMUSG00000021917   signal peptidase complex subunit 1 homolog (S. cerevisiae)
Neospora caninum NCLIV_004530   microsomal signal peptidase subunit SPCS1 domain- containing protein, putative
Oryza sativa 4352133   Os12g0438900
Onchocerca volvulus OVOC1702   Putative signal peptidase complex subunit 1
Plasmodium berghei PBANKA_1011300   signal peptidase complex subunit SPC1, putative
Plasmodium falciparum PF3D7_1433600   signal peptidase complex subunit SPC1, putative
Plasmodium knowlesi PKNH_0420200   signal peptidase complex subunit SPC1, putative
Plasmodium vivax PVX_084850   microsomal signal peptidase 12 kDa subunit, putative
Plasmodium yoelii PY06001   signal peptidase 12kDa subunit
Saccharomyces cerevisiae YJR010C-A   Spc1p
Schistosoma japonicum Sjp_0016650   IPR009542,Microsomal signal peptidase 12 kDa subunit,domain-containing
Schistosoma mansoni Smp_004820   hypothetical protein
Toxoplasma gondii TGME49_321400   microsomal signal peptidase (spc12) domain-containing protein
Trichomonas vaginalis TVAG_177430   conserved hypothetical protein

Essentiality

PF3D7_1433600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C34B2.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_C34B2.10 Caenorhabditis elegans larval arrest wormbase
CELE_C34B2.10 Caenorhabditis elegans larval lethal wormbase
CELE_C34B2.10 Caenorhabditis elegans sterile wormbase
TGME49_321400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1433600 (Plasmodium falciparum), signal peptidase complex subunit SPC1, putative
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