pI: 3.8674 |
Length (AA): 283 |
MW (Da): 31931 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 188 | 2ell (A) | 11 | 168 | 30.00 | 0 | 1 | 0.971671 | -0.7 |
35 | 190 | 2jqd (A) | 10 | 161 | 38.00 | 0 | 1 | 1.08184 | -0.82 |
46 | 190 | 2ell (A) | 28 | 168 | 40.00 | 0 | 1 | 1.06997 | -0.89 |
113 | 172 | 1dce (A) | 506 | 565 | 22.00 | 0 | 1 | 0.603314 | -1.1 |
155 | 265 | 4uos (A) | 70 | 180 | 16.00 | 0 | 0.04 | 0.637526 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128510)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G50690 | leucine-rich repeat (LRR) family protein |
Babesia bovis | BBOV_IV005960 | conserved hypothetical protein |
Brugia malayi | Bm1_26065 | Leucine Rich Repeat family protein |
Caenorhabditis elegans | CELE_T19H12.2 | Protein T19H12.2 |
Caenorhabditis elegans | CELE_F33H2.3 | Protein F33H2.3 |
Cryptosporidium hominis | Chro.10112 | hypothetical protein |
Cryptosporidium parvum | cgd1_930 | U2 snrnp-specific A protein |
Dictyostelium discoideum | DDB_G0281091 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5784 | CG5784 gene product from transcript CG5784-RB |
Echinococcus granulosus | EgrG_001104800 | Acidic leucine rich nuclear phosphoprotein |
Echinococcus multilocularis | EmuJ_001104800 | Acidic leucine rich nuclear phosphoprotein |
Homo sapiens | ENSG00000143401 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
Homo sapiens | ENSG00000140350 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
Homo sapiens | ENSG00000136938 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
Loa Loa (eye worm) | LOAG_02507 | leucine Rich Repeat family protein |
Mus musculus | ENSMUSG00000015749 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
Mus musculus | ENSMUSG00000032249 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
Mus musculus | ENSMUSG00000028333 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
Neospora caninum | NCLIV_035310 | inhibitor-1 of protein phosphatase type 2A, putative |
Oryza sativa | 4333677 | Os03g0668900 |
Plasmodium berghei | PBANKA_1016700 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1427900 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1330800 | hypothetical protein, conserved in Apicomplexan species |
Plasmodium vivax | PVX_085145 | hypothetical protein, conserved |
Plasmodium yoelii | PY06840 | similar to RIKEN cDNA 2810018A15 gene, putative |
Schistosoma japonicum | Sjp_0042580 | Acidic leucine-rich nuclear phosphoprotein 32-related protein, putative |
Schistosoma mansoni | Smp_010940.3 | phosphoprotein |
Schistosoma mansoni | Smp_010940.4 | phosphoprotein |
Schistosoma mansoni | Smp_010940.1 | phosphoprotein |
Schmidtea mediterranea | mk4.000277.04 | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
Schmidtea mediterranea | mk4.015876.00 | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
Schmidtea mediterranea | mk4.003640.01 | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
Schmidtea mediterranea | mk4.003493.01 | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
Toxoplasma gondii | TGME49_271810 | lanp, putative |
Theileria parva | TP01_0399 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T19H12.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_271810 this record | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.