Detailed view for TGME49_291120

Basic information

TDR Targets ID: 265008
Toxoplasma gondii, trafficking protein mon1 subfamily protein
Source Database / ID:  ToxoDB 

pI: 5.0933 | Length (AA): 1085 | MW (Da): 116484 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03164   Trafficking protein Mon1

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Hehl AB Fritz HM Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile VEG Tachyzoite, ME49 Tachyzoite. Gregory
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_128049)

Species Accession Gene Product
Arabidopsis thaliana AT2G28390   SAND family protein
Brugia malayi Bm1_11065   SAND family protein
Candida albicans CaO19.8109   SAND family protein similar to S. cerevisiae MON1 (YGL124C) subunit of Ccz1-Mon1 complex required for homotypic vacuole fusion
Caenorhabditis elegans CELE_F41H10.11   Protein SAND-1
Cryptosporidium hominis Chro.40269   CG11926 gene product
Cryptosporidium parvum cgd4_2380   possible SAND family protein
Dictyostelium discoideum DDB_G0281773   DUF254 family protein
Drosophila melanogaster Dmel_CG11926   Mon1 ortholog
Echinococcus granulosus EgrG_000125100   vacuolar fusion protein MON1 A
Entamoeba histolytica EHI_010680   Sand family protein
Entamoeba histolytica EHI_197260   Sand family protein
Echinococcus multilocularis EmuJ_000125100   vacuolar fusion protein MON1 A
Homo sapiens 22879   MON1 secretory trafficking family member B
Homo sapiens ENSG00000164077   MON1 secretory trafficking family member A
Loa Loa (eye worm) LOAG_08168   SAND family protein
Mus musculus ENSMUSG00000032583   MON1 homolog A (yeast)
Mus musculus ENSMUSG00000078908   MON1 homolog b (yeast)
Neospora caninum NCLIV_042960   hypothetical protein, conserved
Oryza sativa 4324304   Os01g0976000
Onchocerca volvulus OVOC4044  
Plasmodium berghei PBANKA_1365400   vacuolar fusion protein MON1, putative
Plasmodium falciparum PF3D7_1352800   vacuolar fusion protein MON1, putative
Plasmodium knowlesi PKNH_1248200   vacuolar fusion protein MON1, putative
Plasmodium vivax PVX_083535   vacuolar fusion protein MON1, putative
Plasmodium yoelii PY02732   Drosophila melanogaster CG11926 gene product, putative
Saccharomyces cerevisiae YGL124C   Mon1p
Schistosoma japonicum Sjp_0302600   Vacuolar fusion protein MON1 homolog A, putative
Schistosoma mansoni Smp_140440   hypothetical protein
Schmidtea mediterranea mk4.000638.05  
Trypanosoma congolense TcIL3000_10_2310   Trafficking protein Mon1, putative
Toxoplasma gondii TGME49_291120   trafficking protein mon1 subfamily protein
Theileria parva TP02_0458   hypothetical protein
Trichomonas vaginalis TVAG_497390   conserved hypothetical protein
Trichomonas vaginalis TVAG_370460   conserved hypothetical protein

Essentiality

TGME49_291120 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_F41H10.11 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1365400 Plasmodium berghei Essential plasmo
TGME49_291120 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_291120 (Toxoplasma gondii), trafficking protein mon1 subfamily protein
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