pI: 5.0933 |
Length (AA): 1085 |
MW (Da): 116484 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Hehl AB Fritz HM Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite. | Gregory |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128049)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G28390 | SAND family protein |
Brugia malayi | Bm1_11065 | SAND family protein |
Candida albicans | CaO19.8109 | SAND family protein similar to S. cerevisiae MON1 (YGL124C) subunit of Ccz1-Mon1 complex required for homotypic vacuole fusion |
Caenorhabditis elegans | CELE_F41H10.11 | Protein SAND-1 |
Cryptosporidium hominis | Chro.40269 | CG11926 gene product |
Cryptosporidium parvum | cgd4_2380 | possible SAND family protein |
Dictyostelium discoideum | DDB_G0281773 | DUF254 family protein |
Drosophila melanogaster | Dmel_CG11926 | Mon1 ortholog |
Echinococcus granulosus | EgrG_000125100 | vacuolar fusion protein MON1 A |
Entamoeba histolytica | EHI_010680 | Sand family protein |
Entamoeba histolytica | EHI_197260 | Sand family protein |
Echinococcus multilocularis | EmuJ_000125100 | vacuolar fusion protein MON1 A |
Homo sapiens | 22879 | MON1 secretory trafficking family member B |
Homo sapiens | ENSG00000164077 | MON1 secretory trafficking family member A |
Loa Loa (eye worm) | LOAG_08168 | SAND family protein |
Mus musculus | ENSMUSG00000032583 | MON1 homolog A (yeast) |
Mus musculus | ENSMUSG00000078908 | MON1 homolog b (yeast) |
Neospora caninum | NCLIV_042960 | hypothetical protein, conserved |
Oryza sativa | 4324304 | Os01g0976000 |
Onchocerca volvulus | OVOC4044 |
|
Plasmodium berghei | PBANKA_1365400 | vacuolar fusion protein MON1, putative |
Plasmodium falciparum | PF3D7_1352800 | vacuolar fusion protein MON1, putative |
Plasmodium knowlesi | PKNH_1248200 | vacuolar fusion protein MON1, putative |
Plasmodium vivax | PVX_083535 | vacuolar fusion protein MON1, putative |
Plasmodium yoelii | PY02732 | Drosophila melanogaster CG11926 gene product, putative |
Saccharomyces cerevisiae | YGL124C | Mon1p |
Schistosoma japonicum | Sjp_0302600 | Vacuolar fusion protein MON1 homolog A, putative |
Schistosoma mansoni | Smp_140440 | hypothetical protein |
Schmidtea mediterranea | mk4.000638.05 | |
Trypanosoma congolense | TcIL3000_10_2310 | Trafficking protein Mon1, putative |
Toxoplasma gondii | TGME49_291120 | trafficking protein mon1 subfamily protein |
Theileria parva | TP02_0458 | hypothetical protein |
Trichomonas vaginalis | TVAG_497390 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_370460 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F41H10.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1365400 | Plasmodium berghei | Essential | plasmo |
TGME49_291120 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3