Detailed view for TGME49_320210

Basic information

TDR Targets ID: 265107
Toxoplasma gondii, WD domain, G-beta repeat domain containing protein
Source Database / ID:  ToxoDB 

pI: 7.4257 | Length (AA): 515 | MW (Da): 56081 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF08606   Prp19/Pso4-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0061630   GO:ubiquitin protein ligase activity  

GO:0000974   GO:Prp19 complex  

GO:0000398   nuclear mRNA splicing, via spliceosome  
GO:0000151   ubiquitin ligase complex  
GO:0005515   protein binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0016567   protein ubiquitination  
GO:0006281   DNA repair  

Metabolic Pathways

Spliceosome (KEGG)
Ubiquitin mediated proteolysis (KEGG)

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 56 2bay (A) 1 53 36.00 0.00000000003 0.89 0.69 -1.48
123 508 1got (B) 2 340 19.00 0 1 0.76 0.19
208 508 2h14 (A) 43 331 25.00 0 1 0.89 -0.38
4 57 2bay (A) 1 54 35.00 0 0.98 0.613054 -1.01
6 57 2xeu (A) 6 63 17.00 0.023 0.61 0.230771 -0.46
93 176 2rt6 (A) 10 90 21.00 0 0.17 0.362307 -0.5
156 508 4zb4 (B) 149 500 15.00 0 1 0.721637 0.73
205 508 4lg8 (A) 216 503 41.00 0 1 1.05879 -0.29
380 424 5cxb (B) 450 494 36.00 0.027 0.6 0.539879 -0.43
442 515 2hes (X) 115 188 24.00 0.41 0.29 0.305489 0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 merozoite. Hehl AB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Fritz HM Sibley/Greg
Show/Hide expression data references
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_128187)

Species Accession Gene Product
Arabidopsis thaliana AT1G04510   MOS4-associated complex 3A
Arabidopsis thaliana AT2G33340   U-box protein MAC3B
Babesia bovis BBOV_IV006920   WD domain, G-beta repeat containing protein
Brugia malayi Bm1_17445   Hypothetical 55.2 kDa Trp-Asp repeats containing protein T10F2.4 inchromosome III
Candida albicans CaO19.6740   similar to spliceosome component
Candida albicans CaO19.14032   similar to spliceosome component
Cryptosporidium hominis Chro.60560   guanine nucleotide-binding protein
Cryptosporidium parvum cgd6_4850   PRP19 non-snRNP sliceosome component required for DNA repair
Dictyostelium discoideum DDB_G0276803   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG5519   CG5519 gene product from transcript CG5519-RA
Echinococcus granulosus EgrG_000116200   pre mRNA processing factor 19
Echinococcus multilocularis EmuJ_000116200   pre mRNA processing factor 19
Homo sapiens ENSG00000110107   pre-mRNA processing factor 19
Leishmania braziliensis LbrM.27.2690   hypothetical protein, conserved,WD-repeat protein
Leishmania donovani LdBPK_272430.1   hypothetical protein, conserved
Leishmania infantum LinJ.27.2430   hypothetical protein, conserved,WD-repeat protein
Leishmania major LmjF.27.2480   hypothetical protein, conserved,WD-repeat protein
Leishmania mexicana LmxM.27.2480   hypothetical protein, conserved,WD-repeat protein
Loa Loa (eye worm) LOAG_04853   nuclear matrix protein SNEV
Mus musculus ENSMUSG00000024735   PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Neospora caninum NCLIV_010010   HET-R, related
Oryza sativa 4348844   Os10g0466300
Plasmodium berghei PBANKA_0406800   pre-mRNA-processing factor 19, putative
Plasmodium falciparum PF3D7_0308600   pre-mRNA-processing factor 19, putative
Plasmodium knowlesi PKNH_0834100   pre-mRNA-processing factor 19, putative
Plasmodium vivax PVX_119545   pre-mRNA-processing factor 19, putative
Plasmodium yoelii PY02344   hypothetical protein
Saccharomyces cerevisiae YLL036C   E3 ubiquitin-protein ligase PRP19
Schistosoma japonicum Sjp_0205430   ko:K10599 pre-mRNA-processing factor 19, putative
Schistosoma mansoni Smp_082980   hypothetical protein
Schmidtea mediterranea mk4.005466.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003413.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000020.25  
Schmidtea mediterranea mk4.000076.19   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.023338.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.011483.02  
Schmidtea mediterranea mk4.004071.02  
Schmidtea mediterranea mk4.000694.04  
Schmidtea mediterranea mk4.001279.04   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.011493.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.017916.01  
Schmidtea mediterranea mk4.019245.00  
Schmidtea mediterranea mk4.028367.00  
Schmidtea mediterranea mk4.011172.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000116.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.007549.01  
Schmidtea mediterranea mk4.004714.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.006266.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001271.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.014258.02  
Schmidtea mediterranea mk4.009903.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003221.00  
Schmidtea mediterranea mk4.000188.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.023373.01  
Schmidtea mediterranea mk4.009297.03  
Schmidtea mediterranea mk4.003350.00  
Schmidtea mediterranea mk4.030826.01  
Schmidtea mediterranea mk4.000694.00  
Schmidtea mediterranea mk4.000253.04  
Schmidtea mediterranea mk4.003618.05  
Schmidtea mediterranea mk4.003555.00  
Schmidtea mediterranea mk4.014676.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001160.07   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.023296.00  
Schmidtea mediterranea mk4.024695.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.029700.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000142.11  
Schmidtea mediterranea mk4.014575.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003287.00  
Schmidtea mediterranea mk4.022196.00  
Schmidtea mediterranea mk4.026871.00  
Schmidtea mediterranea mk4.002165.00  
Schmidtea mediterranea mk4.000466.00  
Schmidtea mediterranea mk4.005371.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000007.02  
Schmidtea mediterranea mk4.011669.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002963.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.009894.00  
Schmidtea mediterranea mk4.018589.01  
Schmidtea mediterranea mk4.014615.01  
Schmidtea mediterranea mk4.000639.00  
Schmidtea mediterranea mk4.008266.01  
Schmidtea mediterranea mk4.000172.06  
Schmidtea mediterranea mk4.011096.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000295.02  
Schmidtea mediterranea mk4.003125.07   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.029696.00  
Schmidtea mediterranea mk4.008277.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.005158.03  
Schmidtea mediterranea mk4.012492.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.010146.00  
Schmidtea mediterranea mk4.020146.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.013503.02  
Schmidtea mediterranea mk4.011811.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.018206.00  
Schmidtea mediterranea mk4.002638.01  
Schmidtea mediterranea mk4.002024.00  
Schmidtea mediterranea mk4.031799.01  
Schmidtea mediterranea mk4.012466.01  
Schmidtea mediterranea mk4.016627.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003974.03  
Schmidtea mediterranea mk4.005532.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003850.05   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.010195.00  
Schmidtea mediterranea mk4.002247.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003780.04   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000940.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000208.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001394.01  
Schmidtea mediterranea mk4.007754.01  
Schmidtea mediterranea mk4.000985.21   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.006928.00  
Schmidtea mediterranea mk4.008947.03   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.012426.00  
Schmidtea mediterranea mk4.012981.01  
Schmidtea mediterranea mk4.007723.00  
Schmidtea mediterranea mk4.001699.00  
Schmidtea mediterranea mk4.010414.00  
Schmidtea mediterranea mk4.014529.00  
Schmidtea mediterranea mk4.046866.00  
Schmidtea mediterranea mk4.015924.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.008290.00  
Schmidtea mediterranea mk4.002944.04   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.015840.00  
Schmidtea mediterranea mk4.056543.00  
Schmidtea mediterranea mk4.003124.00  
Schmidtea mediterranea mk4.009702.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.016057.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.022939.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000569.01  
Schmidtea mediterranea mk4.004326.03  
Schmidtea mediterranea mk4.005478.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.006367.01  
Schmidtea mediterranea mk4.020311.02  
Schmidtea mediterranea mk4.004577.00  
Schmidtea mediterranea mk4.008022.01  
Schmidtea mediterranea mk4.007211.00  
Schmidtea mediterranea mk4.002730.00  
Schmidtea mediterranea mk4.006834.02  
Schmidtea mediterranea mk4.009394.01  
Schmidtea mediterranea mk4.000584.02  
Schmidtea mediterranea mk4.000671.14  
Schmidtea mediterranea mk4.004950.00  
Schmidtea mediterranea mk4.003785.01  
Schmidtea mediterranea mk4.000092.18  
Schmidtea mediterranea mk4.019007.00  
Schmidtea mediterranea mk4.015938.00  
Schmidtea mediterranea mk4.018246.01  
Schmidtea mediterranea mk4.021417.04   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.014050.01  
Schmidtea mediterranea mk4.011422.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001010.02  
Schmidtea mediterranea mk4.000742.08  
Schmidtea mediterranea mk4.007847.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000932.12  
Schmidtea mediterranea mk4.013963.00  
Schmidtea mediterranea mk4.022457.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.011519.01  
Schmidtea mediterranea mk4.003244.05   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.007552.00  
Schmidtea mediterranea mk4.027504.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.021778.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.005650.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.005043.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001332.05   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000290.16  
Schmidtea mediterranea mk4.000531.10   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002663.00  
Schmidtea mediterranea mk4.004338.01  
Schmidtea mediterranea mk4.018915.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.024263.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.023460.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.024507.01  
Schmidtea mediterranea mk4.018776.01  
Schmidtea mediterranea mk4.010592.02  
Schmidtea mediterranea mk4.017173.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.004615.02  
Schmidtea mediterranea mk4.000531.11  
Schmidtea mediterranea mk4.000288.15   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000661.07   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001697.01  
Schmidtea mediterranea mk4.002646.07   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001765.00  
Schmidtea mediterranea mk4.005717.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.023958.03  
Schmidtea mediterranea mk4.000118.08  
Schmidtea mediterranea mk4.015214.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002574.00  
Schmidtea mediterranea mk4.009464.00  
Schmidtea mediterranea mk4.001118.04   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002126.01  
Schmidtea mediterranea mk4.002268.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001606.05   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.009324.00  
Schmidtea mediterranea mk4.003227.03   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.002017.00  
Schmidtea mediterranea mk4.013813.01  
Schmidtea mediterranea mk4.000311.09  
Schmidtea mediterranea mk4.000042.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.005925.00  
Schmidtea mediterranea mk4.027536.00  
Schmidtea mediterranea mk4.008894.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.006556.01  
Schmidtea mediterranea mk4.000289.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.017197.01  
Schmidtea mediterranea mk4.011984.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.008891.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.015297.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.016435.00  
Schmidtea mediterranea mk4.014960.00  
Schmidtea mediterranea mk4.003666.04  
Schmidtea mediterranea mk4.003267.00  
Schmidtea mediterranea mk4.011680.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.005254.05  
Schmidtea mediterranea mk4.009825.00  
Schmidtea mediterranea mk4.000693.02  
Schmidtea mediterranea mk4.010272.00  
Schmidtea mediterranea mk4.007303.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.007725.03  
Schmidtea mediterranea mk4.007630.02  
Schmidtea mediterranea mk4.008561.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.008620.00  
Schmidtea mediterranea mk4.000717.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003227.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.008113.10   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001206.03  
Schmidtea mediterranea mk4.041067.00  
Schmidtea mediterranea mk4.016428.01  
Schmidtea mediterranea mk4.013365.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003460.01  
Schmidtea mediterranea mk4.006777.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.010516.00  
Schmidtea mediterranea mk4.008197.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.004566.00  
Schmidtea mediterranea mk4.001822.08  
Schmidtea mediterranea mk4.019240.02  
Schmidtea mediterranea mk4.020092.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002389.04  
Schmidtea mediterranea mk4.026297.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.006174.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.004141.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.011183.02  
Schmidtea mediterranea mk4.001296.10  
Schmidtea mediterranea mk4.000589.01  
Schmidtea mediterranea mk4.030483.00  
Schmidtea mediterranea mk4.017464.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000007.01  
Schmidtea mediterranea mk4.015253.00  
Schmidtea mediterranea mk4.009992.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002801.03  
Schmidtea mediterranea mk4.007604.01  
Schmidtea mediterranea mk4.015098.00  
Schmidtea mediterranea mk4.000027.08  
Schmidtea mediterranea mk4.004259.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.002687.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.016229.00  
Schmidtea mediterranea mk4.030378.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000149.04   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001747.04  
Schmidtea mediterranea mk4.000386.20  
Schmidtea mediterranea mk4.014880.03   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.027754.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000013.17   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.013351.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.019477.00  
Schmidtea mediterranea mk4.026604.01  
Schmidtea mediterranea mk4.005826.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.018559.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.003177.05   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002960.03  
Schmidtea mediterranea mk4.001337.07   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.012652.00  
Schmidtea mediterranea mk4.000078.13   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.035630.00  
Schmidtea mediterranea mk4.011870.03   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001461.06   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.012235.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.008171.01  
Schmidtea mediterranea mk4.002343.02  
Schmidtea mediterranea mk4.001832.05  
Schmidtea mediterranea mk4.004121.01  
Schmidtea mediterranea mk4.005403.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.000748.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000630.07   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001974.05   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.009980.02  
Schmidtea mediterranea mk4.003228.00  
Schmidtea mediterranea mk4.018563.00  
Schmidtea mediterranea mk4.013672.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.003426.00  
Schmidtea mediterranea mk4.000370.04  
Schmidtea mediterranea mk4.006604.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.002042.01  
Schmidtea mediterranea mk4.019118.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.003802.04   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.000678.02   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.010913.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.002458.00  
Schmidtea mediterranea mk4.000555.09  
Schmidtea mediterranea mk4.006483.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.019214.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.010373.00  
Schmidtea mediterranea mk4.001121.05  
Schmidtea mediterranea mk4.001465.04  
Schmidtea mediterranea mk4.000100.29  
Schmidtea mediterranea mk4.008970.00  
Schmidtea mediterranea mk4.005923.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001853.00  
Schmidtea mediterranea mk4.028877.00  
Schmidtea mediterranea mk4.004608.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001959.04  
Schmidtea mediterranea mk4.006725.02  
Schmidtea mediterranea mk4.004386.02  
Schmidtea mediterranea mk4.000101.03   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.003029.01  
Schmidtea mediterranea mk4.031349.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001474.02  
Schmidtea mediterranea mk4.011788.01  
Schmidtea mediterranea mk4.047563.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.017249.00  
Schmidtea mediterranea mk4.001598.02  
Schmidtea mediterranea mk4.009483.08  
Schmidtea mediterranea mk4.016038.00  
Schmidtea mediterranea mk4.008420.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001768.01   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.005577.01   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.004479.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.019926.00  
Schmidtea mediterranea mk4.022714.00   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.001219.08  
Schmidtea mediterranea mk4.025174.00  
Schmidtea mediterranea mk4.024040.00   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.027612.00  
Schmidtea mediterranea mk4.004020.02  
Schmidtea mediterranea mk4.026631.00  
Schmidtea mediterranea mk4.004837.01  
Schmidtea mediterranea mk4.000718.05   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.001625.07  
Schmidtea mediterranea mk4.002836.03   Pre-mRNA-processing factor 19
Schmidtea mediterranea mk4.016538.00  
Schmidtea mediterranea mk4.005181.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.007777.00  
Schmidtea mediterranea mk4.009912.00  
Schmidtea mediterranea mk4.015473.01  
Schmidtea mediterranea mk4.003570.00  
Schmidtea mediterranea mk4.024150.02  
Trypanosoma brucei gambiense Tbg.972.2.3270   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5240   pre-mRNA splicing factor 19
Trypanosoma congolense TcIL3000_2_1350   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507801.60   pre-mRNA splicing factor 19, putative
Trypanosoma cruzi TcCLB.509103.10   pre-mRNA splicing factor 19, putative
Toxoplasma gondii TGME49_320210   WD domain, G-beta repeat domain containing protein
Theileria parva TP03_0215   guanine nucleotide-binding protein, putative
Trichomonas vaginalis TVAG_325830   WD-repeat protein, putative
Trichomonas vaginalis TVAG_412620   WD-repeat protein, putative

Essentiality

TGME49_320210 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5240 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.2.5240 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.5240 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.5240 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YLL036C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0406800 Plasmodium berghei Essential plasmo
TGME49_320210 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_320210 (Toxoplasma gondii), WD domain, G-beta repeat domain containing protein
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