pI: 10.8926 |
Length (AA): 506 |
MW (Da): 55645 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
233 | 272 | 2do1 (A) | 0 | 37 | 40.00 | 0.5 | 1 | 0.684451 | -1.11 |
233 | 281 | 1zrj (A) | 0 | 42 | 39.00 | 0 | 1 | 0.655938 | -0.81 |
243 | 273 | 2rno (A) | 13 | 43 | 55.00 | 0.0086 | 1 | 0.809665 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_129159)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G02770 | hypothetical protein |
Babesia bovis | BBOV_I003290 | hypothetical protein |
Brugia malayi | Bm1_45300 | SAP domain containing protein |
Candida albicans | CaO19.7830 | suppressor of the transcriptional defect of Hpr1 |
Candida albicans | CaO19.200 | suppressor of the transcriptional defect of Hpr1 |
Caenorhabditis elegans | CELE_Y53G8AR.6 | Protein Y53G8AR.6 |
Cryptosporidium hominis | Chro.30173 | hypothetical protein |
Cryptosporidium parvum | cgd3_1430 | hypothetical protein |
Dictyostelium discoideum | DDB_G0279663 | SAP DNA-binding domain-containing protein |
Dictyostelium discoideum | DDB_G0277405 | SAP DNA-binding domain-containing protein |
Drosophila melanogaster | Dmel_CG8149 | CG8149 gene product from transcript CG8149-RA |
Echinococcus granulosus | EgrG_000294500 | SAP domain containing ribonucleoprotein |
Echinococcus multilocularis | EmuJ_000294500 | SAP domain containing ribonucleoprotein |
Homo sapiens | ENSG00000205323 | SAP domain containing ribonucleoprotein |
Loa Loa (eye worm) | LOAG_06284 | hypothetical protein |
Mus musculus | ENSMUSG00000078427 | SAP domain containing ribonucleoprotein |
Neospora caninum | NCLIV_022050 | mitochondrial carrier domain-containing protein, putative |
Oryza sativa | 4332457 | Os03g0283300 |
Onchocerca volvulus | OVOC8429 |
|
Plasmodium berghei | PBANKA_0813500 | SAP domain-containing protein, putative |
Plasmodium falciparum | PF3D7_0912500 | SAP domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0710400 | SAP domain-containing protein, putative |
Plasmodium vivax | PVX_099060 | hypothetical protein, conserved |
Plasmodium yoelii | PY07463 | hypothetical protein |
Saccharomyces cerevisiae | YER063W | Tho1p |
Schistosoma japonicum | Sjp_0039100 | IPR003034,DNA-binding SAP,domain-containing |
Schistosoma mansoni | Smp_078090.2 | hypothetical protein |
Schistosoma mansoni | Smp_191380 | hypothetical protein |
Schmidtea mediterranea | mk4.000933.12 | CIP29 protein |
Toxoplasma gondii | TGME49_202870 | SAP domain-containing protein |
Theileria parva | TP03_0177 | hypothetical protein |
Theileria parva | TP03_0178 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y53G8AR.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_202870 this record | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4