pI: 8.7075 |
Length (AA): 833 |
MW (Da): 91324 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
178 | 289 | 5cwj (A) | 3 | 114 | 10.00 | 0 | 0.01 | 0.389854 | -1.74 |
481 | 829 | 4rg1 (A) | 71 | 373 | 54.00 | 0 | 1 | 0.880268 | -0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_128701)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19300 | hypothetical protein |
Babesia bovis | BBOV_IV005600 | conserved hypothetical protein |
Brugia malayi | Bm1_41300 | Uncharacterized ACR, COG2106 family protein |
Candida albicans | CaO19.4563 | similar to S. cerevisiae YMR310C |
Candida albicans | CaO19.12032 | similar to S. cerevisiae YMR310C |
Caenorhabditis elegans | CELE_B0361.6 | Protein B0361.6 |
Cryptosporidium hominis | Chro.70506 | DKFZp566D143.1 |
Cryptosporidium parvum | cgd7_4590 | Mth1. SpoU superfamily - SPOUT methylase |
Dictyostelium discoideum | DDB_G0286505 | DUF171 family protein |
Drosophila melanogaster | Dmel_CG12128 | CG12128 gene product from transcript CG12128-RB |
Homo sapiens | ENSG00000198917 | chromosome 9 open reading frame 114 |
Loa Loa (eye worm) | LOAG_09988 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06822 | hypothetical protein |
Mus musculus | ENSMUSG00000039660 | DNA segment, Chr 2, Wayne State University 81, expressed |
Neospora caninum | NCLIV_014470 | hypothetical protein, conserved |
Oryza sativa | 4335294 | Os04g0244500 |
Onchocerca volvulus | OVOC8717 |
|
Onchocerca volvulus | OVOC8712 |
|
Plasmodium berghei | PBANKA_1012400 | RNA methyltransferase, putative |
Plasmodium falciparum | PF3D7_1432500 | RNA methyltransferase, putative |
Plasmodium knowlesi | PKNH_0419100 | RNA methyltransferase, putative |
Plasmodium vivax | PVX_084920 | RNA methyltransferase, putative |
Plasmodium yoelii | PY04902 | Uncharacterized ACR, COG2106, putative |
Saccharomyces cerevisiae | YMR310C | hypothetical protein |
Saccharomyces cerevisiae | YGR283C | hypothetical protein |
Schmidtea mediterranea | mk4.015284.01 | |
Schmidtea mediterranea | mk4.002309.05 | |
Schmidtea mediterranea | mk4.002309.06 | |
Schmidtea mediterranea | mk4.015284.00 | |
Toxoplasma gondii | TGME49_285950 | hypothetical protein |
Theileria parva | TP01_0368 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_B0361.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0361.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0361.6 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1012400 | Plasmodium berghei | Slow | plasmo |
TGME49_285950 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.