Detailed view for LmjF.36.0510

Basic information

TDR Targets ID: 26526
Leishmania major, mitochondrial carrier protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.8422 | Length (AA): 755 | MW (Da): 83112 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 100 1jc2 (A) 88 162 8.00 0.000000052 0.04 0.22 -0.68
143 419 1okc (A) 3 280 32.00 0 0.99 0.73 -0.41
451 721 1okc (A) 2 293 22.00 0 0.02 0.54 -0.47
5 34 1pon (B) 39 68 10.00 0.048 0 0.128335 -0.28
35 99 2k7b (A) 25 90 8.00 0.0021 0.07 0.213693 -0.9
38 108 1sl8 (A) 112 183 13.00 0.12 0.03 0.19764 -0.2
143 419 1okc (A) 3 280 32.00 0 1 0.642787 0.43
147 419 4c9h (A) 23 295 34.00 0 0.86 0.552489 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126987)

Species Accession Gene Product
Arabidopsis thaliana AT4G01100   adenine nucleotide transporter 1
Arabidopsis thaliana AT4G26180   mitochondrial substrate carrier family protein
Arabidopsis thaliana AT1G14560   mitochondrial CoA transporter
Brugia malayi Bm1_28425   Mitochondrial carrier protein
Candida albicans CaO19.2117   likel mitochondrial carrier protein similar to S. cerevisiae LEU5 (YHR002W) involved in coenzyme A transport
Candida albicans CaO19.804   potential mitochondrial carrier protein similar to S. cerevisiae YPR011C
Candida albicans CaO19.8422   potential mitochondrial carrier protein similar to S. cerevisiae YPR011C
Candida albicans CaO19.9665   likel mitochondrial carrier protein similar to S. cerevisiae LEU5 (YHR002W) involved in coenzyme A transport
Caenorhabditis elegans CELE_F43G9.3   Protein F43G9.3
Dictyostelium discoideum DDB_G0285599   EF-hand domain-containing protein
Dictyostelium discoideum DDB_G0283811   mitochondrial substrate carrier family protein
Dictyostelium discoideum DDB_G0292034   Graves disease carrier family protein
Drosophila melanogaster Dmel_CG4241   alternative testis transcripts open reading frame A
Echinococcus granulosus EgrG_000446900   solute carrier family 25 2
Echinococcus multilocularis EmuJ_000446900   solute carrier family 25 2
Homo sapiens 8034   solute carrier family 25 (mitochondrial carrier), member 16
Homo sapiens ENSG00000181035   solute carrier family 25, member 42
Leishmania braziliensis LbrM.35.0600   mitochondrial carrier protein, putative
Leishmania donovani LdBPK_360540.1   mitochondrial carrier protein, putative
Leishmania infantum LinJ.36.0540   mitochondrial carrier protein, putative
Leishmania major LmjF.36.0510   mitochondrial carrier protein, putative
Leishmania mexicana LmxM.36.0510   mitochondrial carrier protein, putative
Loa Loa (eye worm) LOAG_09735   carrier protein
Mus musculus ENSMUSG00000071253   solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
Mus musculus ENSMUSG00000002346   solute carrier family 25, member 42
Neospora caninum NCLIV_034240   hypothetical protein
Oryza sativa 4327687   Os01g0708900
Oryza sativa 4326348   Os01g0571000
Oryza sativa 4339755   Os05g0585900
Oryza sativa 4328656   Os02g0202400
Oryza sativa 4328781   Os02g0226300
Onchocerca volvulus OVOC1356   Mitochondrial coenzyme A transporter SLC25A42 homolog
Saccharomyces cerevisiae YPR011C   hypothetical protein
Saccharomyces cerevisiae YHR002W   Leu5p
Schistosoma japonicum Sjp_0303720   Solute carrier family 25 member 42, putative
Schistosoma mansoni Smp_142930   mitochondrial carrier protein
Schmidtea mediterranea mk4.001400.01   Graves disease carrier protein
Schmidtea mediterranea mk4.001400.03  
Schmidtea mediterranea mk4.004495.01  
Schmidtea mediterranea mk4.008978.01  
Trypanosoma brucei gambiense Tbg972.10.5960   mitochondrial carrier protein, putative
Trypanosoma brucei Tb927.10.4910   mitochondrial carrier protein
Trypanosoma congolense TcIL3000_10_4100   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.510291.14   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.508659.18   mitochondrial carrier protein, putative
Toxoplasma gondii TGME49_273390   mitochondrial carrier superfamily protein
Trichomonas vaginalis TVAG_262210   tricarboxylate transport protein, putative
Trichomonas vaginalis TVAG_051820   tricarboxylate transport protein, putative

Essentiality

LmjF.36.0510 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.4910 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.4910 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.4910 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.4910 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F43G9.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F43G9.3 Caenorhabditis elegans slow growth wormbase
TGME49_273390 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.36.0510 (Leishmania major), mitochondrial carrier protein, putative
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