pI: 5.9874 |
Length (AA): 276 |
MW (Da): 31094 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
135 | 275 | 1gme (A) | 5 | 149 | 33.00 | 0.0000000099 | 1 | 0.85397 | -0.16 |
168 | 262 | 3gla (A) | 42 | 136 | 39.00 | 0.000075 | 1 | 0.928303 | -1.57 |
170 | 261 | 5ds2 (A) | 3 | 95 | 42.00 | 0 | 1 | 0.885833 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 merozoite, ME49 Oocyst. | Gregory Hehl AB Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_126935)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G27670 | heat shock protein 21 |
Arabidopsis thaliana | AT1G07400 | class I heat shock protein |
Arabidopsis thaliana | AT3G46230 | heat shock protein 17.4 |
Arabidopsis thaliana | AT5G59720 | heat shock protein 18.2 |
Arabidopsis thaliana | AT1G59860 | HSP20-like chaperone |
Arabidopsis thaliana | AT2G29500 | HSP20 family protein |
Arabidopsis thaliana | AT1G53540 | HSP20-like chaperone |
Babesia bovis | BBOV_IV001650 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0280215 | heat shock protein Hsp20 domain-containing protein |
Dictyostelium discoideum | DDB_G0288921 | heat shock protein Hsp20 domain-containing protein |
Drosophila melanogaster | Dmel_CG4460 | Heat shock protein 22 |
Entamoeba histolytica | EHI_125830 | heat shock protein, Hsp20 family |
Leishmania braziliensis | LbrM.29.2420 | heat shock protein 20, putative |
Leishmania donovani | LdBPK_292560.1 | heat shock protein 20, putative |
Leishmania infantum | LinJ.29.2560 | heat shock protein 20, putative |
Leishmania major | LmjF.29.2450 | heat shock protein 20, putative |
Leishmania mexicana | LmxM.08_29.2450 | heat shock protein 20, putative |
Mycobacterium leprae | ML1795 | 18 KDA antigen Hsp18 (HSP 16.7) |
Mycobacterium tuberculosis | Rv0251c | Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) |
Mycobacterium tuberculosis | Rv2031c | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) |
Mycobacterium ulcerans | MUL_2232 | molecular chaperone |
Mycobacterium ulcerans | MUL_1178 | heat shock protein Hsp |
Neospora caninum | NCLIV_041850 | Hsp20/alpha crystallin domain-containing protein, putative |
Neospora caninum | NCLIV_013940 | Heat shock protein 17.4, related |
Oryza sativa | 4332363 | Os03g0267200 |
Oryza sativa | 4332237 | Os03g0245800 |
Oryza sativa | 4332361 | Os03g0267000 |
Oryza sativa | 4325694 | Os01g0135800 |
Oryza sativa | 4332357 | Os03g0266300 |
Oryza sativa | 4325698 | Os01g0136200 |
Oryza sativa | 4332360 | Os03g0266900 |
Oryza sativa | 9267020 | Os05g0296650 |
Oryza sativa | 4325696 | Os01g0136000 |
Oryza sativa | 4325697 | Os01g0136100 |
Plasmodium falciparum | PF3D7_1304500 | small heat shock protein, putative |
Plasmodium knowlesi | PKNH_1404700 | small heat shock protein, putative |
Plasmodium vivax | PVX_122065 | heat shock protein, putative |
Saccharomyces cerevisiae | YBR072W | Hsp26p |
Trypanosoma brucei gambiense | Tbg972.3.3490 | heat shock protein 20, putative |
Trypanosoma brucei | Tb927.3.3330 | heat shock protein 20, putative |
Trypanosoma cruzi | TcCLB.508153.270 | heat shock protein 20, putative |
Trypanosoma cruzi | TcCLB.510323.40 | heat shock protein 20, putative |
Toxoplasma gondii | TGME49_286720 | heat shock protein HSP28 |
Toxoplasma gondii | TGME49_289600 | heat shock protein HSP29 |
Trichomonas vaginalis | TVAG_381290 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_197980 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_287530 | heat shock protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu254 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2063 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.3.3330 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.3330 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.3330 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.3330 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_289600 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_286720 this record | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.